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CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(01): 275-279
DOI: 10.4103/ajns.AJNS_253_17
Case Report

Aggressive primary pediatric intracranial malignant melanoma: Sphinx of the tissue diagnosis

Laxminadh Sivaraju
Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka
,
Nandita Ghosal
1   Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka
,
Anita Mahadevan
2   Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka
,
A Uday Krishna
3   Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka
,
Shilpa Rao
2   Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka
,
Alangar Hegde
Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka
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It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy.

Key-words:

Immunohistochemistry - intracranial - paediatric - primary malignant melanoma - prognosis

Financial support and sponsorship

Nil.




Publication History

Article published online:
09 September 2022

© 2019. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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