Aggressive primary pediatric intracranial malignant melanoma: Sphinx of the tissue diagnosis

Laxminadh Sivaraju; Nandita Ghosal; Anita Mahadevan; A Uday Krishna; Shilpa Rao; Alangar Hegde

doi:10.4103/ajns.AJNS_253_17

Asian Journal of Neurosurgery, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(01): 275-279
DOI: 10.4103/ajns.AJNS_253_17

Case Report

Aggressive primary pediatric intracranial malignant melanoma: Sphinx of the tissue diagnosis

Autor*innen

Laxminadh Sivaraju

Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka
Nandita Ghosal

¹Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka
Anita Mahadevan

²Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka
A Uday Krishna

³Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka
Shilpa Rao

²Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka
Alangar Hegde

Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka

Abstract

It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy.

Key-words:

Immunohistochemistry - intracranial - paediatric - primary malignant melanoma - prognosis

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Referenzen

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