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CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(02): 262-265
DOI: 10.4103/ajns.AJNS_268_19
Review Article

Pediatric cerebellar pilomyxoid astrocytoma: Clinical and radiological findings in three cases

Ghassen Gader
Department of Neurosurgery, Trauma and Burns Center, Ben Arous
,
Ghassen Belkahla
Department of Neurosurgery, Trauma and Burns Center, Ben Arous
,
Nadhir Karmani
1   Department of Neurosurgery, National Institute of Neurology, Tunis
,
Khalil Saadaoui
2   Department of Neurosurgery, Universitary Hospital of Sahloul, Sousse
,
Mouna Rkhami
Department of Neurosurgery, Trauma and Burns Center, Ben Arous
,
Jalel Kallel
1   Department of Neurosurgery, National Institute of Neurology, Tunis
,
Ihsèn Zammel
Department of Neurosurgery, Trauma and Burns Center, Ben Arous
,
Mohamed Badri
Department of Neurosurgery, Trauma and Burns Center, Ben Arous
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Pilomyxoid astrocytomas (PMA) is a particular form of glial tumors distinct from pilocytic astrocytomas (PA). On the last 2016 WHO classification for CNS tumours, no definite grade assignment was proposed for these lesions. They may be more aggressive with a different clinical course compared to PA due to their greater propensity for local recurrence and cerebrospinal dissemination. Most cases arise from the hypothalamic region. Only few studies reported cerebellar localization of the lesion. We report 3 pediatric cases treated for pediatric PMA of the posterior fossa. Clinical, radiological, and prognostic features were reviewed. The age of our patients was between 1 and 9 years old. Signs of intracranial hypertension were found in all patients. One of them presented an increased head circumference and the 2 others had a cerebellar syndrome. Brain CT-scan and MRI displayed a large wellcircumscribed intra-axial solid and cystic posterior fossa tumor. Total surgical resection was performed for all tumors. After a 2 years follow up, no signs of recurrence were noticed. In the literature, PMA been reported with overwhelming majority in children aged between 2 months and 4 years. Despite of many pathological similarities with PAs, PMAs have some specific features in histology, leading to their identification as independent type of glioma. Radiological differential diagnosis between PMAs and Pas can be made using arterial spin labeling imaging, which shows low perfusion parameters in PAs. Clinical and radiological follow up are mandatory do to different natural history and higher rates of local recurrence of this tumor compared to PA. Prognosis is favorable when complete surgical exeresis is possible.

Key-words:

Astrocytoma - neurosurgery - pediatrics

Financial support and sponsorship

Nil.




Publication History

Received: 01 September 2019

Accepted: 19 January 2020

Article published online:
16 August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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