Download PDF
CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(01): 159-161
DOI: 10.4103/ajns.AJNS_293_19
Case Report

Adult-onset seizure disorder secondary to schizencephaly

Abiodun Okunlola
1   Department of Surgery, Federal Teaching Hospital, Ido-Ekiti
2   Department of Surgery, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti
,
Paul Olowoyo
3   Department of Medicine, Federal Teaching Hospital, Ido-Ekiti
4   Department of Medicine, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
,
Cecilia Okunlola
3   Department of Medicine, Federal Teaching Hospital, Ido-Ekiti
,
Olakunle Babalola
1   Department of Surgery, Federal Teaching Hospital, Ido-Ekiti
2   Department of Surgery, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Schizencephaly is a very rare neurological disorder usually discovered during radiological evaluation of children and young adults with seizure disorders or neurodevelopmental anomalies. We present a 66-year-old patient with right-sided hemiatrophy and paresis presenting with an adult-onset seizure disorder. Her seizure was satisfactorily controlled with a single-therapy antiseizure drug. Congenital brain lesions should be part of the differential diagnoses in patients with epilepsy who have body asymmetry dated back to childhood.

Key-words:

Hemibody atrophy - schizencephaly - seizure disorders

Financial support and sponsorship

Nil.




Publication History

Received: 20 September 2019

Accepted: 13 November 2019

Article published online:
16 August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Granata T, Battaglia G. Schizencephaly. Handb Clin Neurol 2008;87:235-46.
  • 2 Tietjen I, Bodell A, Apse K, Mendonza AM, Chang BS, Shaw GM, et al. Comprehensive EMX2 genotyping of a large schizencephaly case series. Am J Med Genet A 2007;143A: 1313-6.
  • 3 Mellado C, Poduri A, Gleason D, Elhosary PC, Barry BJ, Partlow JN, et al. Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort. Am J Med Genet A 2010;152A: 2736-42.
  • 4 Cho WH, Seidenwurm D, Barkovich AJ. Adult-onset neurologic dysfunction associated with cortical malformations. AJNR Am J Neuroradiol 1999;20:1037-43.
  • 5 Kamble V, Lahoti AM, Dhok A, Taori A, Pajnigara N. A rare case of schizencephaly in an adult with late presentation. J Family Med Prim Care 2017;6:450-2.
  • 6 Landy HJ, Ramsay RE, Ajmone-Marsan C, Levin BE, Brown J, Pasarin G, et al. Temporal lobectomy for seizures associated with unilateral schizencephaly. Surg Neurol 1992;37:477-81.
  • 7 Stopa J, Kucharska-Miąsik I, Dziurzyńska-Białek E, Kostkiewicz A, Solińska A, Zając-Mnich M, et al. Diagnostic imaging and problems of schizencephaly. Pol J Radiol 2014;79:444-9.
  • 8 Lopes CF, Cendes F, Piovesana AM, Torres F, Lopes-Cendes I, Montenegro MA, et al. Epileptic features of patients with unilateral and bilateral schizencephaly. J Child Neurol 2006;21:757-60.
  • 9 Denis D, Chateil JF, Brun M, Brissaud O, Lacombe D, Fontan D, et al. Schizencephaly: Clinical and imaging features in 30 infantile cases. Brain Dev 2000;22:475-83.
  • 10 Guerrini R, Carrozzo R. Epileptogenic brain malformations: Clinical presentation, malformative patterns and indications for genetic testing. Seizure 2001;10:532-43.
  • 11 Mighell AS, Johnstone ED, Levene M. Post-natal investigations: Management and prognosis for fetuses with CNS anomalies identified in utero excluding neurosurgical problems. Prenat Diagn 2009;29:442-9.
  • 12 Denis D, Maugey-Laulom B, Carles D, Pedespan JM, Brun M, Chateil JF. Prenatal diagnosis of schizencephaly by fetal magnetic resonance imaging. Fetal Diagn Ther 2001;16:354-9.
  • 13 Halabuda A, Klasa L, Kwiatkowski S, Wyrobek L, Milczarek O, Gergont A. Schizencephaly-diagnostics and clinical dilemmas. Childs Nerv Syst 2015;31:551-6.