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CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(01): 183-186
DOI: 10.4103/ajns.AJNS_315_20
Case Report

A rare case of a high-grade astroblastoma with 5-year follow-up

Lawrence D′Cruze
Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu
,
Sandhya Sundaram
Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu
,
Shruti Iyer
1   Department of MBBS Student, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu
,
Krishnamurthy Ganesh
2   Department of Neurosurgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu
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Astroblastoma is a very rare glial tumor derived from astroblasts. It has been controversial in terms of its features and diagnosis. The objective of this report is to present the findings of the high-grade astroblastoma with a good prognosis in a 21-year-old female who presented to us with diplopia and headache. While imaging led to the foremost differentials of pleomorphic xanthoastrocytoma and Ganglioglioma which are low-grade neoplasms, the final diagnosis was established on microscopy and immunohistochemistry after excision. Treatment protocol included surgery with postoperative radiotherapy and chemotherapy. Due to controversial and limited literature, this tumor poses difficulties in diagnosis and management. This is a rare, successfully managed case of astroblastoma with a positive outcome 5 years after the diagnosis was established. In this case report, we review the steps of diagnosis, the differentials, the pathological and histological features, and the management of this rare entity.

Key-words:

Astroblastoma - brain neoplasm - neuroepithelial - prognosis - treatment outcome

Financial support and sponsorship

Nil.




Publication History

Received: 25 June 2020

Accepted: 18 November 2020

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Bell JW, Osborn AG, Salzman KL, Blaser SI, Jones BV, Chin SS. Neuroradiologic characteristics of astroblastoma. Neuroradiology 2007;49:203-9.
  • 2 Payne C, Batouli A, Stabingas K, Alcindor D, Abdel Aziz K, Pu C, et al. A pediatric tumor found frequently in the adult population: A case of anaplastic astroblastoma in an elderly patient and review of the literature. Case Rep Neurol Med 2017;2017:1607915.
  • 3 Hirano H, Yunoue S, Kaji M, Tsuchiya M, Arita K. Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: A case report. Brain Tumor Pathol 2008;25:25-31.
  • 4 Ahmed KA, Allen PK, Mahajan A, Brown PD, Ghia AJ. Astroblastomas: A surveillance, epidemiology, and end results (SEER)-based patterns of care analysis. World Neurosurg 2014;82:e291-7.
  • 5 Bailey P, Bucy PC. Astroblastomas of the brain. Acta Psychiatr Neurol 1930;5:439-61.
  • 6 Agarwal V, Mally R, Palande DA, Velho V. Cerebral astroblastoma: A case report and review of literature. Asian J Neurosurg 2012;7:98-100.
  • 7 Russell D, Rubenstein L. Pathology of tumors of the central nervous system. J Pathol 1989;158:359.
  • 8 Binesh F, Akhavan A, Navabii H, Mehrabaniyan M. Anaplastic astroblastoma: A rare glial tumour. BMJ Case Rep 2011;2011: bcr0620114323.
  • 9 Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: A summary. Acta Neuropathol 2016;131:803-20.
  • 10 Hammas N, Senhaji N, Alaoui Lamrani MY, Bennis S, Chaoui EM, Fatemi HE. Astroblastoma – A rare and challenging tumor: A case report and review of the literature. J Med Case Rep 2018;12:102.
  • 11 Bonnin JM, Rubinstein LJ. Astroblastomas: A pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery 1989;25:6-13.
  • 12 Lehman NL, Hattab EM, Mobley BC, Usubalieva A, Schniederjan MJ, McLendon RE, et al. Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. Neuro Oncol 2017;19:31-42.
  • 13 Asha U, Mahadevan A, Sathiyabama D, Ravindra T, Sagar BK, Bhat DI, et al. Lack of IDH1 mutation in astroblastomas suggests putative origin from ependymoglial cells? Neuropathology 2015;35:303-11.
  • 14 Mhatre R, Sugur HS, Nandeesh BN, Chickabasaviah Y, Saini J, Santosh V. MN1 rearrangement in astroblastoma: Study of eight cases and review of literature. Brain Tumor Pathol 2019;36:112-20.
  • 15 Sughrue ME, Choi J, Rutkowski MJ, Aranda D, Kane AJ, Barani IJ, et al. Clinical features and post-surgical outcome of patients with astroblastoma. J Clin Neurosci 2011;18:750-4.
  • 16 Caroli E, Salvati M, Esposito V, Orlando ER, Giangaspero F. Cerebral astroblastoma. Acta Neurochir (Wien) 2004;146:629-33.
  • 17 Bhalerao S, Nagarkar R, Adhav A. A case report of high-grade astroblastoma in a young adult. CNS Oncol 2019;8:CNS29.
  • 18 Barakat MI, Ammar MG, Salama HM, Abuhashem S. Astroblastoma: Case report and review of literature. Turk Neurosurg 2016;26:790-4.
  • 19 Merfeld EC, Dahiya S, Perkins SM. Patterns of care and treatment outcomes of patients with astroblastoma: A national cancer database analysis. CNS Oncol 2018;7:CNS13.
  • 20 Salvati M, D'Elia A, Brogna C, Frati A, Antonelli M, Giangaspero F, et al. Cerebral astroblastoma: Analysis of six cases and critical review of treatment options. J Neurooncol 2009;93:369-78.