Download PDF
CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(02): 322-327
DOI: 10.4103/ajns.AJNS_328_19
Original Article

Morphometric analysis of the corpus callosum using cadaveric brain: An anatomical study

Apurba Patra
Department of Anatomy, AIIMS, Bathinda, Punjab
,
Rajan Singla
1   Department of Anatomy, Government Medical College, Patiala, Punjab
,
Priti Chaudhary
Department of Anatomy, AIIMS, Bathinda, Punjab
,
Vishal Malhotra
1   Department of Anatomy, Government Medical College, Patiala, Punjab
2   Department of SPM and Biostatistics, Government Medical College, Patiala, Punjab
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Purpose: The present study was conducted to measure the longitudinal and vertical lengths of the brain hemisphere, longitudinal length of the corpus callosum (CC), and distances of CC from the frontal and occipital poles, in order to define its topographic location within the brain hemispheres. Materials and Methods: Fifty formalin-fixed human brains were dissected in the midsagittal plane. The parameters measured were as follows: (i) straight distance between frontal and occipital pole (AB); (ii) vertical distance (height) between the upper and lower surface of the brain hemisphere (CD); (iii) frontal pole to anterior-most point of CC (EG); (iv) occipital pole to posterior-most point of CC (ZO); (v) anterior-most point to posterior-most point of CC (EZ); and (v) anterior edge of genu to the upper end of lamina terminalis (EF). Results: The mean value of AB, CD, EG, ZO, EZ, and EF was 15.47 ± 0.94 cm, 9.48 ± 0.83 cm, 3.31 ± 0.29 cm, 5.65 ± 0.54 cm, 6.96 ± 0.55 cm, and 2.1 ± 0.39 cm, respectively. AB had the strongest positive correlation with ZO (0.79), whereas CD (height) had it with EZ (0.59). Both AB and CD had a strong positive correlation with EZ. The ratios EZ/AB = 0.45 (P = 0.001) and EZ/CD = 0.73 (P = 0.003) illustrated a steady and significant proportions, present in all the brains studied. Although the mean values of all the parameters were greater in males than in females, only two parameters (ZO and EZ) showed statistically significant (P < 0.05) gender differences. Conclusion: The precise anatomical knowledge regarding the morphometry of CC will provide baseline data for the diagnosis and progression of disease affecting it.

Key-words:

Callosotomy - corpus callosum - intractable epilepsy - length - morphometry

Financial support and sponsorship

Nil.




Publication History

Received: 06 November 2019

Accepted: 11 March 2020

Article published online:
16 August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Fiber composition of the human corpus callosum. Brain Res 1992;598:143-53.
  • 2 Blume H. The surgical treatment of epilepsy. In: Schachter SC, Schomer DL, editors. The Comprehensive Evaluation and Treatment of Epilepsy. San Diego, CA: Academic Press; 1997. p. 197-206.
  • 3 Asadi-Pooya AA, Sharan A, Nei M, Sperling MR. Corpus callosotomy. Epilepsy Behav 2008;13:271-8.
  • 4 Anagnostopoulou S, Mourgel S, Katritsi D. Morphometry of corpus callosum: An anatomical study. Neuroanat 2006;5:20-3.
  • 5 Schulz G, Crooijmans HJ, Germann M, Scheffler K, Müller-Gerbl M, Müller B. Three-dimensional strain fields in human brain resulting from formalin fixation. J Neurosci Methods 2011;202:17-27.
  • 6 Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain 1989;112(Pt 3):799-835.
  • 7 Machado AM, Simon TJ, Nguyen V, McDonald-McGinn DM, Zackai EH, Gee JC. Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Brain Res 2007;1131:197-210.
  • 8 Gonçalves-Ferreira AJ, Herculano-Carvalho M, Melancia JP, Farias JP, Gomes L. Corpus callosum: Microsurgical anatomy and MRI. Surg Radiol Anat 2001;23:409-14.
  • 9 Estruch R, Nicolás JM, Salamero M, Aragón C, Sacanella E, Fernández-Solà J, et al. Atrophy of the corpus callosum in chronic alcoholism. J Neurol Sci 1997;146:145-51.
  • 10 Ankolekar VH, Dsouza A, Hosapatna M, Dsouza AS. Morphometric analysis of corpus callosum in relation to brain size in fetuses of South Indian population. Int J Res Med Sci 2014;2:108-11.
  • 11 Cowell PE, Allen LS, Kertesz A, Zalatimo NS, Denenberg VH. Human corpus callosum: A stable mathematical model of regional neuroanatomy. Brain Cogn 1994;25:52-66.
  • 12 Morino M, Shimizu H, Ohata K, Tanaka K, Hara M. Anatomical analysis of different hemispherotomy procedures based on dissection of cadaveric brains. J Neurosurg 2002;97:423-31.
  • 13 Abou-Khalil BW. When should corpus callosotomy be offered as palliative therapy? Epilepsy Curr 2010;10:9-10.
  • 14 Spencer SS, Spencer DD, Sass K, Westerveld M, Katz A, Mattson R. Anterior, total, and two-stage corpus callosum section: Differential and incremental seizure responses. Epilepsia 1993;34:561-7.
  • 15 Maehara T, Shimizu H. Surgical outcome of corpus callosotomy in patients with drop attacks. Epilepsia 2001;42:67-71.
  • 16 Rahimi SY, Park YD, Witcher MR, Lee KH, Marrufo M, Lee MR. Corpus callosotomy for treatment of pediatric epilepsy in the modern era. Pediatr Neurosurg 2007;43:202-8.
  • 17 Tanriverdi T, Olivier A, Poulin N, Andermann F, Dubeau F. Long-term seizure outcome after corpus callosotomy: A retrospective analysis of 95 patients. J Neurosurg 2009;110:332-42.
  • 18 Kawai K, Shimizu H, Yagishita A, Maehara T, Tamagawa K. Clinical outcomes after corpus callosotomy in patients with bihemispheric malformations of cortical development. J Neurosurg 2004;101:7-15.
  • 19 Kim DS, Yang KH, Kim TG, Chang JH, Chang JW, Choi JU, et al. The surgical effect of callosotomy in the treatment owf intractable seizure. Yonsei Med J 2004;45:233-40.
  • 20 Nádvornik P, Krupa P, Chrastina J, Smrcka V, Novák Z, Zborilová E. Circular stereotactic callosotomy: A preliminary report. Technical note. Acta Neurochir (Wien) 1997;139:359-60.