Download PDF
CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(03): 488-493
DOI: 10.4103/ajns.AJNS_482_20
Original Article

Central nervous system tuberculoma in the corpus callosum mimicking a butterfly glioma: literature review of radiological findings and our experience

Claudia Scudieri
1   Department of Neurosurgery and Gamma Knife Radiosurgery, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan
2   Department of Neurological Surgery, Galliera Hospitals, Genova
,
Fotios Kalfas
3   Department of Neurosurgery, Padua University Hospital, Padua
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Context: Central nervous system (CNS) tuberculoma is the most common form of intracranial parenchymal tuberculosis (TB) which accounts for approximately 40% of misdiagnosed brain lesions mimicking intracranial tumors. The most common sites are the cerebral hemispheres, basal ganglia, cerebellum, and brainstem. Materials and Methods: Radiological findings of corpus callosum tuberculomas have been described and set in relation with the available literature. Results: Corpus callosum tuberculomas are extremely rare, with only five cases reported in the current literature. Even though isolated CNS tuberculoma of the corpus callosum without systemic TB in immunocompetent patients occurs rarely, as in our case, it should be considered in the differential diagnosis of solitary corpus callosum lesions. Conclusions: Careful evaluation of the neuroradiological images with adequate clinicoradiological correlation allows for accurate diagnosis and ensures the proper and timely care.

Key-words:

Central nervous system - corpus callosum lesion - intracranial tuberculosis - tuberculoma

Financial support and sponsorship

Nil.




Publication History

Received: 27 October 2020

Accepted: 06 March 2021

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J. British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect 2009;59:167-87.
  • 2 Brismar J, Hugosson C, Larsson SG, Lundstedt C, Nyman R. Imaging of tuberculosis. III. Tuberculosis as a mimicker of brain tumour. Acta Radiol 1996;37:496-505.
  • 3 Fath-Ordoubadi F, Lane RJ, Richards PG. Histological surprise: Callosal tuberculoma presenting as malignant glioma. J Neurol Neurosurg Psychiatry 1997;63:98-9.
  • 4 Montgomery LC. Hemiplegia due to tuberculosis of the corpus callosum. Can Med Assoc J 1933;29:375-8.
  • 5 Psimaras D, Bonnet C, Heinzmann A, Cárdenas G, Hernández José Luis S, Tungaria A, et al. Solitary tuberculous brain lesions: 24 new cases and a review of the literature. Rev Neurol (Paris) 2014;170:454-63.
  • 6 Nelson CA, Zunt JR. Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients. Clin Infect Dis Off Publ Infect Dis Soc Am 2011;53:915-26.
  • 7 Krishnan N, Robertson BD, Thwaites G. The mechanisms and consequences of the extra-pulmonary dissemination of Mycobacterium tuberculosis. Tuberc Edinb Scotl 2010;90:361-6.
  • 8 Kumar D, Sheoran RK, Bansal SK, Arora OP. Revisiting the CNS tuberculosis with emphasis on giant tuberculomas and introducing the “outer rim excrescence sign”. Neuroradiol J 2011;24:357-66.
  • 9 Gupta RK, Kumar S. Central nervous system tuberculosis. Neuroimaging Clin 2011;21:795-814.
  • 10 Bargalló J, Berenguer J, García-Barrionuevo J, Ubeda B, Bargalló N, Cardenal C, et al. The “target sign”: Is it a specific sign of CNS tuberculoma? Neuroradiology 1996;38:547-50.
  • 11 Khatri GD, Krishnan V, Antil N, Saigal G. Magnetic resonance imaging spectrum of intracranial tubercular lesions: One disease, many faces. Pol J Radiol 2018;83:e524-35.