Extra-axial desmoplastic medulloblastoma in adult cerebellopontine angle: Case report and noninvasive molecular subgrouping utilizing magnetic resonance imaging-based radiomics nomogram

Sundus Ali; Adnan Qasim; Shahzaib Tasdique; Muhammad Sarwar; Shahzad Shams

doi:10.4103/ajns.AJNS_525_20

Asian Journal of Neurosurgery, Table of Contents

CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(03): 618-622
DOI: 10.4103/ajns.AJNS_525_20

Case Report

Extra-axial desmoplastic medulloblastoma in adult cerebellopontine angle: Case report and noninvasive molecular subgrouping utilizing magnetic resonance imaging-based radiomics nomogram

Sundus Ali

Department of Neurosurgery, Mayo Hospital, King Edward Medical University, Lahore

,

Adnan Qasim

Department of Neurosurgery, Mayo Hospital, King Edward Medical University, Lahore

,

Shahzaib Tasdique

Department of Neurosurgery, Mayo Hospital, King Edward Medical University, Lahore

,

Muhammad Sarwar

Department of Neurosurgery, Mayo Hospital, King Edward Medical University, Lahore

,

Shahzad Shams

Department of Neurosurgery, Mayo Hospital, King Edward Medical University, Lahore

› Author Affiliations

Abstract

Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 12 cases reported in pure extra-axial location. None was predicted on preoperative imaging while the most common misdiagnosis was petrous meningioma. We add the 13^th case to this list, attempting to reiterate the radiological features for preoperative prediction of this rare pathology on conventional magnetic resonance imaging (MRI). Molecular subtyping also is not yet reported for adult extra-axial CPA MB. We propose the routine use of MRI-based nomograms, in atypical CPA extra-axial masses, for noninvasive prediction of molecular subgroup, especially in resource-limited setups that lack the facility of genetic profiling.

Key-words:

Adult - cerebellopontine angle - medulloblastoma - radiomics

Full Text

References

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