Extra-axial cerebello-pontine angle medulloblastoma in an infant: A rare case report with review of literature

Medulloblastoma is a fairly common neoplastic growth seen majorly in children, presenting as an intra-axial midline mass arising from the cerebellar vermis. However, its presentation as an extra-axial mass in the cerebellopontine angle (CPA) is extremely rare, such that, only 39 cases have been reported in the world literature till 2016. Only one case has ever been reported of an extra-axial CPA medulloblastoma in an infant; who was aged 1 year. We present a case report of an 8-month-old infant, with an extra-axial CPA medulloblastoma and discuss its management strategy.

Key-words:

Cerebellopontine angle - chemotherapy - medulloblastoma - radiotherapy

Financial support and sponsorship

Nil.

Publication History

Received: 22 February 2021

Accepted: 18 April 2021

Article published online:
16 August 2022

• References

• 1 Boukobza M, Polivka M. Medulloblastoma of the cerebellopontine angle in a child. A case report and review of the literature. J Mol Biomark Diagn 2016;7:284.
• 2 Millard NE, de Braganca KC. Medulloblastoma. J Child Neurol 2016;31:1341-53.
• 3 Bhaskar MK, Jaiswal M, Ojha BK, Singh SK, Chandra A, Meel M, et al. Extra-axial cerebellopontine angle medulloblastoma in an infant. Pediatr Neurosurg 2017;52:122-6.
• 4 Kumar R, Bhowmick U, Kalra SK, Mahapatra AK. Pediatric cerebellopontine angle medulloblastomas. J Pediatr Neurosci 2008;3:127-30.
• 5 Jaiswal AK, Mahapatra AK, Sharma MC. Cerebellopointine angle medulloblastoma. J Clin Neurosci 2004;11:42-5.
• 6 Bailey P, Cushing H. Medulloblastoma cerebelli, a common type of mid-cerebellar glioma of childhood. Arch Neurol Psychiatr 1925;14:192-224.
• 7 Hubbard JL, Scheithauer BW, Kispert DB, Carpenter SM, Wick MR, Law ER Jr. Adult cerebellar medulloblastomas: The Pathological radiological and clinical disease spectrum. J Neurosurg 1989;70:536-44.
• 8 Raaf J, Kernohan JW. Relation of abnormal collections of cells in posterior medullary velum of cerebellum to origin of medulloblastoma. Arch Neurol Psychiatry 1944;52:163-9.
• 9 Stevenson L, Echlim F. Nature and origin of some tumors of cerebellum: Medullobastoma. Arch Neurol Psychiatry 1934;31:93-109.
• 10 Noiphithak R, Yindeedej V, Thamwongskul C. Cerebellopontine angle medulloblastoma with extensive nodularity in a child: Case report and review of the literature. Childs Nerv Syst 2017;33:839-42.
• 11 Goudihalli SR, Pathak A, Brar R, Mundi I. Reappraisal of cerebellopontine angle medulloblastomas: Report of a fatal case and lessons learned. Interdiscip Neurosurg 2018;12:20-3.
• 12 Pant I, Chaturvedi S, Gautam VK, Pandey P, Kumari R. Extra-axial medulloblastoma in the cerebellopontine angle: Report of a rare entity with review of literature. J Pediatr Neurosci 2016;11:331-4.
• 13 Yamasaki F, Kurisu K, Satoh K, Arita K, Sugiyama K, Ohtaki M, et al. Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 2005;235:985-91.
• 14 Bull JG, Saunders DE, Clark CA. Discrimination of paediatric brain tumours using apparent diffusion coefficient histograms. Eur Radiol 2012;22:447-57.
• 15 Wu G, Pang H, Ghimire P, Liu GH. Magnetic resonance spectroscopy and diffusion weighted imaging findings of medulloblastoma in 3.0T MRI: A retrospective analysis of 17 cases. Neural Regen Res 2012;15:2554-9.
• 16 Britton BH. Adult medulloblastoma, neurotological manifestations. Ann Otol 1975;84:364-7.
• 17 Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol 2016;131:803-20.
• 18 Kumar R, Achari G, Mishra A, Chhabra DK. Medulloblastomas of the cerebellopontine angle. Neurol India 2001;49:380-3.
• 19 Cordon BJ, Strauss LC, Killmond T, Carson BS, Wharam MD, Kumar AJ et al. Cisplatin, Ara C. Etoposide (PAE) in treatment of recurrent childhood brain tumors. Journal of Neuro-Oncology 1991;11:57-63.