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CC BY-NC-ND 4.0 · Eur J Dent 2018; 12(02): 317-326
DOI: 10.4103/ejd.ejd_347_17
Review Article
European Journal of Dentistry

Comparison of the biocompatibility of calcium silicate-based materials to mineral trioxide aggregate: Systematic review

Natália Gomes de Oliveira
1   Department of Dentistry and Endodontics, Faculty of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil
,
Pollyana Rodrigues de Souza Araújo
1   Department of Dentistry and Endodontics, Faculty of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil
,
Marina Torreão da Silveira
1   Department of Dentistry and Endodontics, Faculty of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil
,
Ana Paula Veras Sobral
2   Department of Patology, Faculty of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil
,
Marianne de Vasconcelos Carvalho
1   Department of Dentistry and Endodontics, Faculty of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil
› Author Affiliations
Further Information

Publication History

Publication Date:
16 September 2019 (online)

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ABSTRACT

The objective of this systematic review was to evaluate the biocompatibility and interaction of bioceramic materials with animal and human mesenchymal cells in vitro and in vivo and to compare them with mineral trioxide aggregate (MTA). Two independent researchers conducted PubMed/Medline, Web of Science, and Scopus searches to identify studies published in English, without restrictions on year of publication using the following keywords: “root canal sealer,” “root repair material,” “cytotoxicity,” and “bioceramics.” The articles were selected following the PRISMA statement. A total of 1486 titles were identified in the initial search. However, only 18 studies met the inclusion and exclusion criteria. The results showed that bioceramic materials have biological properties similar to those of MTA, including low cytotoxicity as well as promoting cell proliferation and adhesion, low expression of inflammatory cytokines, and reduced pulp inflammation. This systematic review therefore suggests that the choice of repair bioceramic materials or MTA based on biocompatibility should be the professional's decision.

Key words:

Bioceramics - cytotoxicity - root canal sealer - root repair material
 

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