Effect of Different Matrix Metalloproteinase Inhibitors on Shear Bond Strength of Composite Attached to Primary Teeth Dentin

Abstract

Aim: This study is aimed to evaluate the effect of exogenous matrix metalloproteinases (MMPs) inhibitors on immediate shear bond strength (SBS) of resin composite attached to primary teeth dentin. Methods: Sixty extracted anterior primary teeth were selected. A dentin block (6.0 mm × 6.0 mm × 2.0 mm) was obtained from each tooth. All dentin blocks (n = 60) were pretreated for 60 s with either 0.01 M phosphate-buffered saline (pH 7.2) in the control group (Group I), chlorhexidine (CHX) 2% (Group II), doxycycline (DOX) solution 2% (Group III), and ethylenediaminetetraacetic acid (EDTA) 17% (Group IV) before applying etch-and-rinse adhesive system (Adper Single Bond 2). After adhesive application, composite resin (Filtek 3M, USA) was applied, and then, SBS values were determined with a universal testing machine. Results: There were no significant differences between SBS values of DOX, EDTA, and the control group (P < 0.05). SBS values reduced when CHX was applied, although the reduction was not statistically significant (P = 0.961). The DOX group showed the highest bond strength values (8.82 ± 3.29), which was significantly greater than the CHX (P = 0.026). Conclusion: Based on the results, pretreatment with MMPs inhibitors was not advantageous with regard to improving the immediate SBS of composite attached to primary teeth dentin.

Keywords

Composite - laboratory research - matrix metalloproteinase inhibitors - primary dentin - shear bond strength

Financial support and sponsorship

Nil.

Clinical significance

Although MMP inhibitors have been proven effective in improving bond strength of composite to permanent teeth, they might not be efficient in primary teeth.

Publication History

Article published online:
01 November 2021

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