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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2021; 13(02): 67-73
DOI: 10.4103/ijmbs.ijmbs_30_21
Original Article

Cancer mortality pattern in a resource-poor country: A Case study of a teaching hospital in the southeast region of Nigeria

Chinedu Ndukwe
1   Department of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe University, Awka
,
Chinwe Ndukwe
2   Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Uyo
,
Kenechi Ike
3   Department of Histopathology, Nnamdi Azikiwe University Teaching Hospital, Uyo
,
Uchechukwu Eziagu
4   Department of Anatomic Pathology, University of Uyo Teaching Hospital, Uyo
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Background: There are many studies on the pattern and incidence of cancer, but there are few documented works on cancer mortality (CM). Even fewer are African studies on CM that encompass all cancers and reveal the relative contributions of the various cancers to the overall burden of CM. This retrospective study was therefore performed to determine the types and patterns of cancer deaths in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Southeast, Nigeria, during the 10-year period from 2010 to 2019. Materials and Methods: Data were collected from the death data files in the mortuary unit of the department of anatomic pathology. These death data document the cause of death as issued by the attending medical/surgical/oncology teams or the pathologist that performed an autopsy on the deceased. Data collected included the deceased's age, sex, and underlying cause and date of death. Results: One thousand one hundred and sixty-six deaths (representing 10.3% of all hospital deaths) were due to cancers. There were 472 (40.5%) males and 694 (59.5%) females in the series (P < 0.001), giving a male-to-female ratio of 1:1.5. The mean age for males was 53.2 ± 22.6 years and that of females was 48.3 ± 17.9 years. A bimodal age distribution pattern of CM was noticed with peaks in the 0–10-year and 51–60-year age groups (P < 0.001). The second peak occurs a decade earlier in females (51–60 years) than in males (61–70 years). In terms of type, breast, liver, and hematological malignancies were among the top three causes of cancer deaths. Cancers of the breast, liver, hematolymphoid tissues, ovary, and cervix were the largest contributors to the cancer-associated mortality burden among females. Prostate, liver, hematological, pancreas, and colorectal malignancies were the leading cause of CM among males. Hematological malignancies resulted in the death of more children and young adults younger than 31 years. Breast and liver cancers accounted for the most cancer deaths that affected patients in the 31–60-year-old age group, while deaths due to prostate cancer predominated in those above 60 years of age. Conclusion: Cancers have remained a vital cause of mortality in our setting. Screening for premalignant lesions, early detection, and treatment of cancers are therefore keys to improving dismal outcomes.

Key-words:

Cancer - mortality - Nigeria - Nnewi

Financial support and sponsorship

Nil.




Publikationsverlauf

Eingereicht: 08. Mai 2021

Angenommen: 09. Juni 2021

Artikel online veröffentlicht:
14. Juli 2022

© 2021. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Zhang YB, Pan XF, Chen J, Cao A, Zhang YG, Xia L, et al. Combined lifestyle factors, incident cancer, and cancer mortality: A systematic review and meta-analysis of prospective cohort studies. Br J Cancer 2020;122:1085-93.
  • 2 Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
  • 3 Busolo DS, Woodgate RL. Cancer prevention in Africa: A review of the literature. Glob Health Promot 2015;22:31-9.
  • 4 Lyimo EP, Rumisha SF, Mremi IR, Mangu CD, Kishamawe C, Chiduo MG, et al. Cancer mortality patterns in Tanzania: A retrospective hospital-based study, 2006-2015. JCO Glob Oncol 2020;6:224-32.
  • 5 Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.
  • 6 Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends--An update. Cancer Epidemiol Biomarkers Prev 2016;25:16-27.
  • 7 Rubagumya F, Greenberg L, Manirakiza A, DeBoer R, Park PH, Mpunga T, et al. Increasing global access to cancer care: Models of care with non-oncologists as primary providers. Lancet Oncol 2017;18:1000-2.
  • 8 Wiredu EK, Armah HB. Cancer mortality patterns in Ghana: A 10-year review of autopsies and hospital mortality. BMC Public Health 2006;6:159.
  • 9 Akinde OR, Phillips AA, Oguntunde OA, Afolayan OM. Cancer mortality pattern in Lagos University Teaching Hospital, Lagos, Nigeria. J Cancer Epidemiol 2015;2015:842032.
  • 10 Obiorah CC, Nwafor CC. Cancer mortality in the Niger Delta Region of Nigeria: A case study of the University of Port Harcourt Teaching Hospital. Niger Med J 2019;60:268-72.
  • 11 Obiorah CC. Cause specific and trends of mortality in Nigeria : A six-year study of a tertiary hospital. Int J Med Med Sci 2020;12:1-7.
  • 12 Made F, Wilson K, Jina R, Tlotleng N, Jack S, Ntlebi V, et al. Distribution of cancer mortality rates by province in South Africa. Cancer Epidemiol 2017;51:56-61.
  • 13 World Health Organization. Noncommunicable Diseases (NCD) Country Profiles. Geneva: World Health Organization; 2018.
  • 14 American Cancer Society. Global Cancer Facts and Figures 4th ed. Atlanta: American Cancer Society; 2018.
  • 15 Nigeria Source: Globocan; 2018. Available from: https://gco.iarc.fr/today/data/factsheets/populations/566-nigeria-fact-sheets.pdf. [Last accessed on 2020 Oct 26].
  • 16 Silas OA, Musa J, Afolaranmi TO, Sagay AS, Evans CT, Achenbach CJ et al. Predictors of mortality from a Population-Based Cancer Registry Data in Jos, Nigeria : A resource-limited setting. Front Med (Lausanne) 2020;7:227.
  • 17 Beau AB, Andersen PK, Vejborg I, Lynge E. Limitations in the effect of screening on breast cancer mortality. J Clin Oncol 2018;36:2988-94.
  • 18 Goodman PJ, Tangen CM, Darke AK, Lucia MS, Ford LG, Minasian LM, et al. Long-term effects of finasteride on prostate cancer mortality. N Engl J Med 2019;380:393-4.
  • 19 Chen SL, Wang SC, Ho CJ, Kao YL, Hsieh TY, Chen WJ, et al. Prostate cancer mortality-to-incidence ratios are associated with cancer care disparities in 35 countries. Sci Rep 2017;7:40003.
  • 20 Shaukat A, Dostal A, Menk J, Church TR. BMI Is a risk factor for colorectal cancer mortality. Dig Dis Sci 2017;62:2511-7.