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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2019; 11(01): 5-15
DOI: 10.4103/ijmbs.ijmbs_6_19
Review Article

Fat facts: An overview of adipose tissue and lipids

Nasr Anaizi
1   Department of Physiology, University of Benghazi, Benghazi
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The term fat evokes a multitude of ideas, images, and prejudices. It encompasses the different types of adipose tissue (AT) and cellular components as well as the myriad of lipid molecules. The AT and lipid molecules throughout the body carry out scores of vital functions ranging from thermal insulation to energy homeostasis to signal transduction. A fact that is not generally appreciated is that in addition to its roles in energy balance and thermoregulation, the AT is also an integral part of both the endocrine and immune systems. Fatty acids (FAs) are the primary building blocks of most lipids. They serve as fuel, structural components, and regulatory molecules (mediators). Most of the free FAs in the body are either obtained from the diet or released by the AT (lipolysis). However, most of the short-chain FAs such as propionate and butyrate are generated in the colon by the fermentation of dietary fiber by the gut microbiota. In addition to providing fuel for the colon enterocytes, these molecules act on specific G protein-coupled receptors in the gut cells stimulating the release of glucagon-like peptide-1 and peptide YY simultaneously improving insulin sensitivity and curbing appetite. The essential FAs linoleic and α-linolenic give rise to two distinct classes of omega FAs, n-6 and n-3, respectively, and hence to more complex lipid derivatives (eicosanoids) which are involved in virtually all aspects of cellular function including immunomodulation and inflammation. These include prostacyclins, thromboxanes, leukotrienes, and epoxyeicosatrienoic acids.

Key-words:

Adipokines - adipose - free fatty acids - lipids

Financial support and sponsorship

Nil.




Publikationsverlauf

Eingereicht: 17. Januar 2019

Angenommen: 23. Januar 2019

Artikel online veröffentlicht:
07. Juli 2022

© 2019. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: Its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne) 2016;7:30.
  • 2 Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity (Silver Spring) 2015;23:512-8.
  • 3 Nakamura Y, Nakamura K. Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability. Pflugers Arch 2018;470:823-37.
  • 4 Dempersmier J, Sul HS. Shades of brown: A model for thermogenic fat. Front Endocrinol (Lausanne) 2015;6:71.
  • 5 Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001;104:531-43.
  • 6 Siegel MJ, Hildebolt CF, Bae KT, Hong C, White NH. Total and intraabdominal fat distribution in preadolescents and adolescents: Measurement with MR imaging. Radiology 2007;242:846-56.
  • 7 Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, et al. Dynamics of fat cell turnover in humans. Nature 2008;453:783-7.
  • 8 Arner P, Spalding KL. Fat cell turnover in humans. Biochem Biophys Res Commun 2010;396:101-4.
  • 9 Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 2011;478:110-3.
  • 10 Strawford A, Antelo F, Christiansen M, Hellerstein MK. Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O. Am J Physiol Endocrinol Metab 2004;286:E577-88.
  • 11 Anaizi NH. Measuring obesity: Fat or fit. Ibnosina J Med BS 2016;8:3-14.
  • 12 Woolcott OO, Bergman RN. Relative fat mass (RFM) as a new estimator of whole-body fat percentage – A cross-sectional study in American adult individuals. Sci Rep 2018;8:10980.
  • 13 Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity (Silver Spring) 2015;23:512-8.
  • 14 Gati A, Kouidhi S, Marrakchi R, El Gaaied A, Kourda N, Derouiche A, et al. Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict. Oncoimmunology 2014;3:e27810.
  • 15 Jung UJ, Choi MS. Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 2014;15:6184-223.
  • 16 Cohen P, Spiegelman BM. Brown and beige fat: Molecular parts of a thermogenic machine. Diabetes 2015;64:2346-51.
  • 17 Lo KA, Sun L. Turning WAT into BAT: A review on regulators controlling the browning of white adipocytes. Biosci Rep 2013;33. pii: e00065.
  • 18 Kiefer FW. The significance of beige and brown fat in humans. Endocr Connect 2017;6:R70-R79.
  • 19 Contreras C, Nogueiras R, Diéguez C, Rahmouni K, López M. Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway. Redox Biol 2017;12:854-63.
  • 20 Martínez-Beamonte R, Lou-Bonafonte JM, Martínez-Gracia MV, Osada J. Sphingomyelin in high-density lipoproteins: Structural role and biological function. Int J Mol Sci 2013;14:7716-41.
  • 21 Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, et al. The host microbiome regulates and maintains human health: A primer and perspective for non-microbiologists. Cancer Res 2017;77:1783-812.
  • 22 Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: Functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol 2012;165:622-32.
  • 23 Khan MJ, Gerasimidis K, Edwards CA, Shaikh MG. Role of gut microbiota in the aetiology of obesity: Proposed mechanisms and review of the literature. J Obes 2016;2016:7353642.
  • 24 Lin HV, Frassetto A, Kowalik EJ Jr., Nawrocki AR, Lu MM, Kosinski JR, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 2012;7:e35240.
  • 25 Chakraborti CK. New-found link between microbiota and obesity. World J Gastrointest Pathophysiol 2015;6:110-9.
  • 26 Anez-Bustillos L, Dao DT, Baker MA, Fell GL, Puder M, Gura KM, et al. Intravenous fat emulsion formulations for the adult and pediatric patient: Understanding the differences. Nutr Clin Pract 2016;31:596-609.
  • 27 Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H. Paleolithic nutrition for metabolic syndrome: Systematic review and meta-analysis. Am J Clin Nutr 2015;102:922-32.
  • 28 Goddard AD, Watts A. Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biol 2012;10:27.
  • 29 Takamitsu E, Otsuka M, Haebara T, Yano M, Matsuzaki K, Kobuchi H, et al. Identification of human N-myristoylated proteins from human complementary DNA resources by cell-free and cellular metabolic labeling analyses. PLoS One 2015;10:e0136360.
  • 30 Palczewski K, Orban T. From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci 2013;36:139-64.
  • 31 Miyamoto J, Hasegawa S, Kasubuchi M, Ichimura A, Nakajima A, Kimura I, et al. Nutritional signaling via free fatty acid receptors. Int J Mol Sci 2016;17:450.
  • 32 Hara T, Kimura I, Inoue D, Ichimura A, Hirasawa A. Free fatty acid receptors and their role in regulation of energy metabolism. Rev Physiol Biochem Pharmacol 2013;164:77-116.
  • 33 Mensink RP. Effects of Saturated Fatty Acids on Serum Lipids and Lipoproteins: A Systematic Review and Regression Analysis. Geneva: World Health Organization; 2016.
  • 34 Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146-55.
  • 35 Zock PL, Blom WA, Nettleton JA, Hornstra G. Progressing insights into the role of dietary fats in the prevention of cardiovascular disease. Curr Cardiol Rep 2016;18:111.
  • 36 Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010;91:535-46.
  • 37 Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, et al. Re-evaluation of the traditional diet-heart hypothesis: Analysis of recovered data from Minnesota coronary experiment (1968-73). BMJ 2016;353:i1246.
  • 38 Dehghan M, Mente A, Zhang X, Swaminathan S, Li W, Mohan V, et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study. Lancet 2017;390:2050-62.
  • 39 O'Connor AA. Decades-old study, rediscovered, challenges advice on saturated fat. N Y Times 2016;2016. Available from: https://well.blogs.nytimes.com. [Released on 2016 Apr 13; Last accessed on 2019 Feb 02]
  • 40 Kromhout D, Geleijnse JM, Menotti A, Jacobs DR Jr. The confusion about dietary fatty acids recommendations for CHD prevention. Br J Nutr 2011;106:627-32.
  • 41 Anaizi N. The dietary fat-heart disease hypothesis: An ongoing debate. Ibnosina J Med Biomed Sci 2018;10:3-8.
  • 42 Spector AA, Kim HY. Discovery of essential fatty acids. J Lipid Res 2015;56:11-21.
  • 43 Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015;15:511-23.