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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(02): 223-225
DOI: 10.4103/ijmpo.ijmpo_115_16
Case Report

Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features

Ons Boudaouara
Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia
,
Chiraz Chaari
Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia
,
Abdelkhalek Hassini
Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia
,
Tahya Sellami Boudaouara
Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype.

Keywords

Breast neoplasms - diagnosis - immunohistochemistry - myofibroblastoma - staining and labeling


Publication History

Article published online:
06 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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