A Case of Accidental Vincristine Overdose and Effective use of Therapeutic Plasma Exchange in Its Management

Hari Goyal; Anil Khetarpal; Amit Jain

doi:10.4103/ijmpo.ijmpo_116_20

Indian Journal of Medical and Paediatric Oncology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(05): 770-772
DOI: 10.4103/ijmpo.ijmpo_116_20

Practitioner Section

A Case of Accidental Vincristine Overdose and Effective use of Therapeutic Plasma Exchange in Its Management

Hari Goyal

¹Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India

,

Anil Khetarpal

²Department of Blood Bank and Transfusion Medicine, Artemis Hospital, Gurugram, Haryana, India

,

Amit Jain

¹Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India

› Institutsangaben

Abstract

Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a case of Hodgkin lymphoma being treated with adriamycin, bleomycin, vinblastine and dacarbazine protocol, where vincristine was accidently administrated instead of vinblastine due to its “look-alike, sound-alike” nature. The patient developed severe toxicity due to the same, which was effectively managed by therapeutic plasma exchange.

Keywords

Look-alike - sound-alike drugs - medication error - overdose - therapeutic plasma exchange - vincristine

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Referenzen

References
1 Saha AS, Islam MF, Bhattacharya S, Giri PP. Clinical presentation of inadvertent intrathecal vincristine masquerading guillain-barre syndrome. Indian J Hematol Blood Transfus 2016; 32: 59-61
2 Chae L, Moon HS, Kim SC. Overdose of vincristine: Experience with a patient. J Korean Med Sci 1998; 13: 334-8
3 Kosmidis HV, Bouhoutsou DO, Varvoutsi MC, Papadatos J, Stefanidis CG, Vlachos P. et al. Vincristine overdose: Experience with 3 patients. Pediatr Hematol Oncol 1991; 8: 171-8
4 Schwartz J, Padmanabhan A, Aqui N, Balogun RA, Connelly-Smith L, Delaney M. et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society for Apheresis: The Seventh Special Issue. J Clin Apheresis 2016; 31: 149-62
5 Ibrahim RB, Balogun RA. Medications and therapeutic apheresis procedures: Are we doing our best?. J Clin Apher 2013; 28: 73-7
6 Estlin EJ, Ronghe M, Burke GA, Yule SM. The clinical and cellular pharmacology of vincristine, corticosteroids, l-asparaginase, anthracyclines and cyclophosphamide in relation to childhood acute lymphoblastic leukaemia. Br J Haematol 2000; 110: 780-90