Abstract
Background: Adenoid cystic carcinoma (ACC) is an uncommon tumor with nonspecific clinicoradiological
features thereby masquerading other nonneoplastic and neoplastic entities. Materials and Methods: Cases of ACC were retrospectively reviewed over a period of 4 years. The clinical
details of these patients including fine-needle aspiration cytology (FNAC) and imaging
findings were retrieved. Diagnosis was confirmed on histomorphology and supplemented
with immunohistochemistry (IHC). Results:: Thirty cases of ACC were included in the study. Mean patient age was 55.5 years
with a slight female preponderance. Among the 30 ACCs, 10 (33.4%) were located in
submandibular gland, 7 (23.4%) in parotid gland, 6 (20%) in sublingual gland, 2 (6.7%)
in lung and one each (3.33%) in nasal cavity, breast, cervix, lip, and skin of face.
Preoperative imaging was suggestive of malignancy in 29 cases while a single case
of parotid gland ACC was misdiagnosed as benign salivary gland neoplasm. FNAC was
performed in 29 cases with a diagnostic accuracy of 82.7%. Histopathological examination
showed characteristic features of ACC in all cases with perineural invasion seen in
7 cases. On IHC, positivity for cytokeratin was seen in all cases, cluster of differentiation
117 in 24 cases, thyroid transcription factor-1 in two cases and human epidermal growth
factor receptor/neu in two cases. All cases were negative for estrogen receptor and
progesterone receptor IHC. Mean Ki-67 score was 47.8%. Conclusion: ACCs are notorious tumors showing slow growth kinetics with propensity for perineural
invasion, late recurrences, and distant metastasis. It should be kept in mind as a
differential diagnosis at unusual sites other than salivary glands.
Keywords
Adenoid cystic carcinoma - fine-needle aspiration cytology - perineural - salivary
glands
