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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S25-S32
DOI: 10.4103/ijmpo.ijmpo_144_17
Original Article

Thermo Mammogram as a Tool to Assess Response to Neoadjuvant Chemotherapy in Breast Carcinoma

Subbiah Shanmugam
Department of Surgical Oncology, Government Royapettah Hospital, Chennai, Tamil Nadu, India
,
Gopu Govindasamy
Department of Surgical Oncology, Government Royapettah Hospital, Chennai, Tamil Nadu, India
,
Sujay Susikar
Department of Surgical Oncology, Government Royapettah Hospital, Chennai, Tamil Nadu, India
,
Muniasamy Palaniyandi
Department of Surgical Oncology, Government Royapettah Hospital, Chennai, Tamil Nadu, India
› Institutsangaben Financial support and sponsorship Nil.
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Abstract

Introduction: Response to neoadjuvant chemotherapy (NACT) is predicted by clinical examination alone in locally advanced breast carcinoma. This study uses thermo mammogram (TMG) to assess the response. Aim and Objectives: The aim is to study TMG changes during NACT in breast cancer and predict response to NACT in locally advanced carcinoma and to compare clinical response with TMG response/changes in any form. Patients and Methods: All patients with locally advanced breast cancer who had treated with NACT were included in this study. Baseline TMG picture was taken using illumina360° (digital robotic rotational thermography device for 360 degree view of each breast) system before chemotherapy. TMG was repeated before next cycle. All patients were also assessed clinically during and after each cycle of chemotherapy. To assess the potential of TMG in predicting tissue response to chemotherapy, the precool, postcool, and the temperature difference between precool and postcool before every cycle were analyzed. Results: A total of 19 patients were analyzed. Eight patients had complete clinical response, six patients had partial response, and five patients had static disease. Median of precool, temperature difference between precool and postcool for patients between no response and complete response did not show statistically significant difference. However, the median of postcool spot temperature showed statistically significant difference. Median of postcool temperature difference for patients between partial response and complete response showed statistically significant difference. The median of postcool spot temperature for patients with no response and partial response did not show statistically significant difference. Precool temperature difference for all the visits showed no statistically significant difference. Conclusion: This preliminary study suggests that the TMG has potential for monitoring NACT response in breast cancer patients. Postcool temperature measurement is an early indicator of response to NACT.

Keywords

Assessment of response - breast carcinoma - thermo mammogram


Publikationsverlauf

Artikel online veröffentlicht:
24. Mai 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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