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DOI: 10.4103/ijmpo.ijmpo_148_17
Pseudoprogression in Rectal Gastrointestinal Stromal Tumor
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Abstract
Although gastrointestinal stromal tumors (GISTs) are common mesenchymal intestinal neoplasms, rectal GISTs are rare mesenchymal tumors of the GI tract. We describe a case of rectal GIST in a 63-year-old male. The patient was given imatinib monotherapy and was further followed up by contrast-enhanced computed tomography abdomen for response assessment. We conclude that although rectal GISTs are extremely uncommon, it should be considered as a differential when any rectal mass is incidentally detected. Oncologists and radiologists should also be aware of pseudoprogression phenomena of GISTs in evaluating tumor response.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2021
© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Nishida T, Hirota S. Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol 2000; 15: 1293-301
- 2 Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 1983; 7: 507-19
- 3 Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S. et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279: 577-80
- 4 Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: An analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol 2005; 100: 162-8
- 5 Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J. et al. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: A clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol 2001; 25: 1121-33
- 6 Hong X, Choi H, Loyer EM, Benjamin RS, Trent JC, Charnsangavej C. et al. Gastrointestinal stromal tumor: Role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib. Radiographics 2006; 26: 481-95
- 7 Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ. et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002; 33: 459-65
- 8 Eisenberg BL, Judson I. Surgery and imatinib in the management of GIST: Emerging approaches to adjuvant and neoadjuvant therapy. Ann Surg Oncol 2004; 11: 465-75
- 9 Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C. et al. Malignant gastrointestinal stromal tumor: Distribution, imaging features, and pattern of metastatic spread. Radiology 2003; 226: 527-32
- 10 Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M. Gastrointestinal stromal tumors: Radiologic features with pathologic correlation. Radiographics 2003; 23: 283-304, 456
- 11 Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B. et al. Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era – a population-based study in Western Sweden. Cancer 2005; 103: 821-9
- 12 Tirkes T, Hollar MA, Tann M, Kohli MD, Akisik F, Sandrasegaran K. et al. Response criteria in oncologic imaging: Review of traditional and new criteria. Radiographics 2013; 33: 1323-41
- 13 Choi H. Response evaluation of gastrointestinal stromal tumors. Oncologist 2008; 13 (02) Suppl 4-7