RSS-Feed abonnieren
PDF herunterladen
DOI: 10.4103/ijmpo.ijmpo_148_17
Pseudoprogression in Rectal Gastrointestinal Stromal Tumor
Authors
Financial support and sponsorship Nil.
Abstract
Although gastrointestinal stromal tumors (GISTs) are common mesenchymal intestinal neoplasms, rectal GISTs are rare mesenchymal tumors of the GI tract. We describe a case of rectal GIST in a 63-year-old male. The patient was given imatinib monotherapy and was further followed up by contrast-enhanced computed tomography abdomen for response assessment. We conclude that although rectal GISTs are extremely uncommon, it should be considered as a differential when any rectal mass is incidentally detected. Oncologists and radiologists should also be aware of pseudoprogression phenomena of GISTs in evaluating tumor response.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2021
© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Nishida T, Hirota S. Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol 2000; 15: 1293-301
- 2 Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 1983; 7: 507-19
- 3 Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S. et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279: 577-80
- 4 Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: An analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol 2005; 100: 162-8
- 5 Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J. et al. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: A clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol 2001; 25: 1121-33
- 6 Hong X, Choi H, Loyer EM, Benjamin RS, Trent JC, Charnsangavej C. et al. Gastrointestinal stromal tumor: Role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib. Radiographics 2006; 26: 481-95
- 7 Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ. et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002; 33: 459-65
- 8 Eisenberg BL, Judson I. Surgery and imatinib in the management of GIST: Emerging approaches to adjuvant and neoadjuvant therapy. Ann Surg Oncol 2004; 11: 465-75
- 9 Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C. et al. Malignant gastrointestinal stromal tumor: Distribution, imaging features, and pattern of metastatic spread. Radiology 2003; 226: 527-32
- 10 Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M. Gastrointestinal stromal tumors: Radiologic features with pathologic correlation. Radiographics 2003; 23: 283-304, 456
- 11 Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B. et al. Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era – a population-based study in Western Sweden. Cancer 2005; 103: 821-9
- 12 Tirkes T, Hollar MA, Tann M, Kohli MD, Akisik F, Sandrasegaran K. et al. Response criteria in oncologic imaging: Review of traditional and new criteria. Radiographics 2013; 33: 1323-41
- 13 Choi H. Response evaluation of gastrointestinal stromal tumors. Oncologist 2008; 13 (02) Suppl 4-7