Indian Journal of Medical and Paediatric Oncology, Table of Contents CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 287-290DOI: 10.4103/ijmpo.ijmpo_151_16 Original Article Neurolymphomatosis: A Surreal Presentation of Lymphoma Shikha Khandelwal Gujarat Imaging Centre, Post Graduate Institute of Radiology, Samved Hospital, Ahmedabad, Gujarat, India , Suvinay Saxena Department of Radiodiagnosis, Gujarat Imaging Centre, Post Graduate Institute of Radiology, Samved Hospital, Ahmedabad, Gujarat, India , Disha J Hansalia Gujarat Imaging Centre, Post Graduate Institute of Radiology, Samved Hospital, Ahmedabad, Gujarat, India › Author Affiliations Recommend Article Abstract PDF Download Abstract Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET). Results and Conclusion: MRI and PET-CT are imaging modalities of choice for evaluation of patients with lymphoma and suspected neural involvement. Treatment of neurolymphomatosis consists of focal radiotherapy and high-dose methotrexate therapy. Keywords KeywordsLymphoma - magnetic resonance imaging - neurolymphomatosis - positron emission tomography-computed tomography imaging PDF (1655 kb) References References 1 Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. Neurolymphomatosis: An International Primary CNS Lymphoma Collaborative Group report. Blood 2010;115:5005-11. 2 Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neuro Oncol 2003;5:104-15. 3 Chamberlain MC, Fink J. Neurolymphomatosis: A rare metastatic complication of diffuse large B-Cell lymphoma. J Neurooncol 2009;95:285-8. 4 Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, et al. Clinicopathological features of neuropathy associated with lymphoma. Brain 2013;136:2563-78. 5 Baehring J, Cooper D. Neurolymphomatosis. J Neurooncol 2004;68:243-4. 6 Trojan A, Jermann M, Taverna C, Hany TF. Fusion PET-CT imaging of neurolymphomatosis. Ann Oncol 2002;13:802-5. 7 Kelly JJ, Karcher DS. Lymphoma and peripheral neuropathy: A clinical review. Muscle Nerve 2005;31:301-13. 8 Beristain X, Azzarelli B. The neurological masquerade of intravascular lymphomatosis. Arch Neurol 2002;59:439-43. 9 Bokstein F, Goor O, Shihman B, Rochkind S, Even-Sapir E, Metser U, et al. Assessment of neurolymphomatosis by brachial plexus biopsy and PET/CT. Report of a case. J Neurooncol 2005;72:163-7. 10 Viali S, Hutchinson DO, Hawkins TE, Croxson MC, Thomas M, Allen JP, et al. Presentation of intravascular lymphomatosis as lumbosacral polyradiculopathy. Muscle Nerve 2000;23:1295-300. 11 Crush AB, Howe BM, Spinner RJ, Amrami KK, Hunt CH, Johnson GB, et al. Malignant involvement of the peripheral nervous system in patients with cancer: Multimodality imaging and pathologic correlation. Radiographics 2014;34:1987-2007. 12 Gan HK, Azad A, Cher L, Mitchell PL. Neurolymphomatosis: Diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol 2010;12:212-5. 13 Ogose A, Hotta T, Morita T, Higuchi T, Umezu H, Imaizumi S, et al. Diagnosis of peripheral nerve sheath tumors around the pelvis. Jpn J Clin Oncol 2004;34:405-13. 14 Kanter P, Zeidman A, Streifler J, Marmelstein V, Even-Sapir E, Metser U, et al. PET-CT imaging of combined brachial and lumbosacral neurolymphomatosis. Eur J Haematol 2005;74:66-9. 15 Rosso SM, de Bruin HG, Wu KL, van den Bent MJ. Diagnosis of neurolymphomatosis with FDG PET. Neurology 2006;67:722-3. 16 Oztürk E, Arpaci F, Kocaoglu M, Arslan N, Bulakbasi N, Ozgüven M. Detection of widespread neurolymphomatosis with 18F-FDG PET. Eur J Nucl Med Mol Imaging 2006;33:975-6. 17 Habermann TM, Weller EA, Morrison VA, et al. Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol. 2006;24:3121-7. 18 Masatoshi N, Kouhei Y, Yuji N, Shin-ichi K, Tadakazu K, Akifumi TK. Neurolymphomatosis as a manifestation of relapsed primary cardiac lymphoma. Int J of Hematology 2010;92:79-680.
