Olanzapine: The Game-Changer “Antiemetic”

Manikandan Dhanushkodi

doi:10.4103/ijmpo.ijmpo_151_19

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(02): 274-276
DOI: 10.4103/ijmpo.ijmpo_151_19

Drug Review

Olanzapine: The Game-Changer “Antiemetic”

Manikandan Dhanushkodi

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

› Author Affiliations

Abstract

Chemotherapy-induced nausea and vomiting (CINV) is significantly debilitating and worsens the quality of life. Olanzapine, an atypical antipsychotic drug, also has an antiemetic potential. Studies have shown that olanzapine-based regimens have similar efficacy as compared to aprepitant in patients receiving highly emetogenic chemotherapy (HEC). National Comprehensive Cancer Network guidelines also recommends olanzapine-based regimen in HEC. Olanzapine, palonosetron, dexamethasone regimen is a cost-effective option in resource-limited settings in patients receiving HEC.

Keywords

Chemotherapy-induced nausea and vomiting - highly emetogenic chemotherapy - olanzapine

Full Text

References

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