RSS-Feed abonnieren
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.4103/ijmpo.ijmpo_153_17
ALK-Negative Anaplastic Large-Cell Lymphoma Diagnosed on Liver Biopsy in a Child Presenting with Nonresolving Pyrexia
Financial support and sponsorship Nil.![](https://www.thieme-connect.de/media/10.1055-s-00050348/2019S01/lookinside/thumbnails/10-4103-ijmpo-ijmpo_153_17_169-1.jpg)
Abstract
ALK-negative anaplastic large-cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma occurring in adulthood. We report a case of a 13-year-old boy who presented with a 6-month history of fever with jaundice and pancytopenia. Computed tomography abdomen showed multiple hypodense lesions in the liver. Bone marrow biopsy revealed necrotizing granulomas. The patient was treated with antitubercular treatment but failed to show a response. Liver biopsy performed subsequently showed features of ALK-negative ALCL. Extranodal involvement in ALK-negative ALCL can have unusual clinical presentations. This case highlights the utility of timely tissue diagnosis in patients with nonresolving pyrexia and organ lesions on imaging.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2021
© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Mason DY, Harris NL, Delsol G, Stein H, Campo E, Kinney MC. et al. Anaplastic large cell lymphoma, ALK-negative. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H. et al. editors WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: IARC; 2008: 317-9
- 2 Ferreri AJ, Govi S, Pileri SA, Savage KJ. Anaplastic large cell lymphoma, ALK-negative. Crit Rev Oncol Hematol 2013; 85: 206-15
- 3 Agnelli L, Mereu E, Pellegrino E, Limongi T, Kwee I, Bergaggio E. et al. Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma. Blood 2012; 120: 1274-81
- 4 Xu X. ALK-negative anaplastic large cell lymphoma primarily involving the bronchus: A case report and literature review. Int J Clin Exp Pathol 2014; 7: 460-3
- 5 Tsavari A, Koulia K, Skafida E, Myoteri D, Zisi A, Grammatoglou X. et al. Primary anaplastic large-cell lymphoma, ALK1 negative, of the liver: A case report. OA Case Rep 2013; 2: 20
- 6 Mishra P, Dang M, Gajendra S, Lipi L, Sachdev R. Primary pancreatic ALK negative anaplastic large cell lymphoma. Pathology 2015; 47: 85-6
- 7 Mosunjac MB, Sundstrom JB, Mosunjac MI. Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: Autopsy study of five cases. Croat Med J 2008; 49: 660-8
- 8 Wellmann A, Thieblemont C, Pittaluga S, Sakai A, Jaffe ES, Siebert P. et al. Detection of differentially expressed genes in lymphomas using cDNA arrays: Identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas. Blood 2000; 96: 398-404
- 9 Bonzheim I, Geissinger E, Roth S, Zettl A, Marx A, Rosenwald A. et al. Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood 2004; 104: 3358-60
- 10 ten Berge RL, Oudejans JJ, Ossenkoppele GJ, Meijer CJ. ALK-negative systemic anaplastic large cell lymphoma: Differential diagnostic and prognostic aspects – A review. J Pathol 2003; 200: 4-15
- 11 Savage KJ, Harris NL, Vose JM, Ullrich F, Jaffe ES, Connors JM. et al. ALK-anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the international peripheral T-cell lymphoma project. Blood 2008; 111: 5496-504