Paraneoplastic Palmar Fasciitis and Polyarthritis Syndrome in a Metastatic Breast Cancer Patient: Rare Case Report

Abstract

Palmar fasciitis and polyarthritis syndrome (PFAPS) is a rare paraneoplastic event that has been reported mainly in ovarian cancers. Clinical diagnosis of PFAPS is characterized by the diagnosis of neoplasm with accompanying flexion contractures, inflammatory fasciitis, fibrosis, and generalized arthritis of the hands. Since first published report, only rare few additional cases of PFPAS have been reported. In this case report, we describe a patient with metastatic breast cancer who subsequently developed PFPAS in association with advanced breast cancer. She had clinical rheumatological symptoms course parallel to her primary breast cancer disease status.

Keywords

Metastatic breast cancer - palmar fasciitis and polyarthritis syndrome - paraneoplastic syndrome - steroids

• References

• 1 Medsger TA, Dixon JA, Garwood VF. Palmar fasciitis and polyarthritis associated with ovarian carcinoma. Ann Intern Med 1982; 96: 424-31
• 2 Nadal R, McMahan ZH, Antonarakis ES. Paraneoplastic palmar fasciitis and polyarthritis syndrome in a patient with advanced prostate cancer. Clin Genitourin Cancer 2013; 11: e15-23
• 3 Pelosof LC, Gerber DE. Paraneoplastic syndromes: An approach to diagnosis and treatment. Mayo Clin Proc 2010; 85: 838-54
• 4 Naschitz JE, Rosner I. Musculoskeletal syndromes associated with malignancy (excluding hypertrophic osteoarthropathy). Curr Opin Rheumatol 2008; 20: 100-5
• 5 Santra G. Paraneoplastic palmar fasciitis and polyarthritis syndrome. J Assoc Physicians India 2009; 57: 79-81
• 6 Qureshi AA, Saavedra A. Palmar fasciitis and polyarthritis syndrome in patients with ovarian cancer – A case report and review of the literature. Hand (N Y) 2011; 6: 220-3
• 7 Manger B, Schett G. Palmar fasciitis and polyarthritis syndrome-systematic literature review of 100 cases. Semin Arthritis Rheum 2014; 44: 105-11