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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S1-S5
DOI: 10.4103/ijmpo.ijmpo_218_17
Original Article

Bone Marrow Infiltration by Nonhematopoetic Small Round Cell Tumors: A Clinicopathological Study from a Tertiary Care Centre in South India

Triveni Bhopal
Departments of Pathology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
,
Abid Hussain
Departments of Pathology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
,
Sai Mallikarjun
Departments of Pathology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
,
Sree Lakshmi
Departments of Pathology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
,
Sudha Sinha
Departments of Medical Oncology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Objectives: The objective of this study to comprehensively analyze bone marrow (BM) infiltration by nonhematological round cell tumors. Materials and Methods: A total of 206 diagnosed cases of small round blue cell tumors (excluding lymphomas) during a period of 2½ years, referred for BM examination were included in the study. Clinical details were obtained from medical records. BM aspiration (BMA) and BM biopsies (BMBx) were performed under local anesthesia for staging workup. BMBx were studied for cellularity, presence of infiltration by round cells (nonhematopoietic), histologic patterns (island/nests and diffuse sheets), fibrosis, necrosis and other secondary changes. Immunohistochemistry panel was used depending on the morphology. Results: The cases included age range from 45 days to 25 years with a median age of 12 years. There was a male predominance with male:female 1.5:1. Among these, 37/206 cases (17.9%) were positive for BM involvement (BMI) on BMBx. Of these, 24 cases were neuroblastoma (64.8%), 9 cases Ewing’s sarcoma/primitive neuroectodermal tumor (24.3%), and 4 Rhabdomyosarcoma (10.8). BMBx was done in all the 206 cases. Among these, 37/206 cases were positive for BMI on BMBx while 35/206 cases were positive on BM imprints and 33/206 cases were positive on BMA. Conclusion: Detection of metastasis in the BM has both therapeutic and prognostic significance. BMBx are complementary in the diagnosis of small round cell tumor.

Keywords

Bone marrow biopsy - Ewings/primitive neuroectodermal tumor - marrow infiltration - neuroblastoma - nonhematopoetic small round cell tumors


Publication History

Article published online:
24 May 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Samson M. Fait remarkable de diathesecancereuse. Gaz Med Paris 1834; 2: 140
    Google Scholar
  • 2 Rohr K, Hegglin R. Tumorzellen in sternapunktat. Dtsch Arch Klin Med 1936; 179: 61-79
    Google Scholar
  • 3 Asif N, Hassan K, Yasmeen N. Bone marrow infiltration in small blue cell tumours. J Islamabad Med Dent Coll (JIMDC) 2013; 2: 3-8
    Google Scholar
  • 4 Papac RJ. Bone marrow metastases. A review. Cancer 1994; 74: 2403-13
    CrossrefPubMedGoogle Scholar
  • 5 Schleiermacher G, Delattre O. Detection of micrometastases and circulating tumour cells using molecular biology technics in solid tumours. Bull Cancer 2001; 88: 561-70
    PubMedGoogle Scholar
  • 6 Contreras E, Ellis LD, Lee RE. Value of the bone marrow biopsy in the diagnosis of metastatic carcinoma. Cancer 1972; 29: 778-83
    CrossrefPubMedGoogle Scholar
  • 7 Leland J, MacPherson B. Hematologic findings in cases of mammary cancer metastatic to bone marrow. Am J Clin Pathol 1979; 71: 31-5
    CrossrefPubMedGoogle Scholar
  • 8 Rubins JM. The role of myelofibrosis in malignant leukoerythroblastosis. Cancer 1983; 51: 308-11
    CrossrefPubMedGoogle Scholar
  • 9 Mishra P, Das S, Kar R, Jacob SE, Basu D. Non-haematopoietic malignancies metastasing to the bone marrow: A 5 year record-based descriptive study from a tertiary care centre in South India. Indian J Cancer 2014; 51: 30-4
    CrossrefPubMedGoogle Scholar
  • 10 Rafiq H, Khurshid R, Zia R, Hayee A. Frequency of bone invasion and metastasis in round cell tumors of pediatric age groups. Biomedica 2007; 23: 8-11
    Google Scholar
  • 11 Kumar L, Majhi U, Shanta V. Frequency of bone marrow involvement in non-haematological malignancies. J Assoc Physicians India 1990; 38: 553-5
    PubMedGoogle Scholar
  • 12 Singh G, Krause JR, Breitfeld V. Bone marrow examination: For metastatic tumor: Aspirate and biopsy. Cancer 1977; 40: 2317-21
    CrossrefPubMedGoogle Scholar
  • 13 Ingle JN, Tormey DC, Tan HK. The bone marrow examination in breast cancer: Diagnostic considerations and clinical usefulness. Cancer 1978; 41: 670-4
    CrossrefPubMedGoogle Scholar
  • 14 Basu D, Singh T, Shinghal RN. Micrometastasis in bone marrow in breast cancer. Indian J Pathol Microbiol 1994; 37: 159-64
    PubMedGoogle Scholar
  • 15 Sharma S, Murari M. Bone marrow involvement by metastatic solid tumors. Indian J Pathol Microbiol 2003; 46: 382-4
    PubMedGoogle Scholar
  • 16 Bearden JD, Ratkin GA, Coltman CA. Comparison of the diagnostic value of bone marrow biopsy and bone marrow aspiration in neoplastic disease. J Clin Pathol 1974; 27: 738-40
    CrossrefPubMedGoogle Scholar
  • 17 Imran R, Aejaz S, Banday MA, Ahmad SN. Extrarenal Wilms’ tumour with bone marrow involvement: An index case report. Chin Ger J Clin Oncol 2010; 9: 295-7
    CrossrefGoogle Scholar
  • 18 Krsková L, Mrhalová M, Hilská I, Sumerauer D, Drahokoupilová E, Múdry P. et al. Detection and clinical significance of bone marrow involvement in patients with rhabdomyosarcoma. Virchows Arch 2010; 456: 463-72
    CrossrefPubMedGoogle Scholar