Langerhans Cell Histiocytosis in a 5-Year-Old Girl: A Case Report and Review of Literature

Shruthi Rao; Shruthi Hegde; PS Gopinath Thilak; G Subhas Babu; Vidya Ajila; Urvashi Shetty; Sajad Ahmad Buch

doi:10.4103/ijmpo.ijmpo_258_17

Indian Journal of Medical and Paediatric Oncology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S176-S180
DOI: 10.4103/ijmpo.ijmpo_258_17

Practitioner Section

Langerhans Cell Histiocytosis in a 5-Year-Old Girl: A Case Report and Review of Literature

Shruthi Rao

Consultant, General Dental Practitioner, Mangala Health Centre, Padil, Karnataka, India

,

Shruthi Hegde

Departments of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Karnataka, India

,

PS Gopinath Thilak

Departments of Oral and Maxillofacial Surgery and Oral Pathology and Microbiology, A B Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Karnataka, India

,

G Subhas Babu

Departments of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Karnataka, India

,

Vidya Ajila

Departments of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Karnataka, India

,

Urvashi Shetty

Departments of Oral Pathology and Microbiology, A B Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Karnataka, India

,

Sajad Ahmad Buch

Departments of Research Scholar, Yenepoya Dental College, Yenopoya (Deemed to be) University, Mangaluru, Karnataka, India

› Institutsangaben

Abstract

Langerhans cell histiocytosis (LCH) is an uncommon hematological disorder affecting infants and young children. LCH is a rare disorder of the reticuloendothelial system associated with proliferation of Langerhans cells and mature eosinophils. LCH can involve any bone, but the most common are pelvis, ribs, skull, long bones, vertebra, and facial bones. In the skull, frontal and parietal bones are commonly involved followed by the jaws, where mandible is more commonly affected than the maxilla. In this article, we report a case of LCH in a 5-year-old child involving the mandible. Swelling of one side of the face and aggressive periosteal reaction led to the diagnosis of monostotic LCH. The manuscript also summarizes the results of a literature search in PubMed of reported cases of LCH over the past 10 years.

Keywords

Langerhans cell histiocytosis - mandible - periostitis

Volltext

Referenzen

References
1 Rao DG, Trivedi MV, Havale R, Shrutha SP. A rare and unusual case report of Langerhans cell histiocytosis. J Oral Maxillofac Pathol 2017; 21: 140-4
2 Jindal M, Sharma VK, Ahmed I, Agrawal A. Langerhans cell histiocytosis of maxilla and mandible in 6 years old child: A case report. Int J Clin Pediatr Dent 2009; 2: 45-9
3 Golai S, Nimbeni B, Patil SD, Kakanur M, Paul S. Langerhans histiocytosis in a child-diagnosed by oral manifestations. J Clin Diagn Res 2015; 9: ZD09-11
4 Can IH, Kurt A, Ozer E, Sarı N, Samim E. Mandibular manifestation of Langerhans cell histiocytosis in children. Oral Oncol Extra 2005; 41: 174-7
5 Schepman KP, Radden BG, Van der Waal I. Langerhans’ cell histiocytosis of the jaw bones. Report of 11 cases. Aust Dent J 1998; 43: 238-41
6 Bartnick A, Friedrich RE, Roeser K, Schmelzle R. Oral Langerhans cell histiocytosis. J Craniomaxillofac Surg 2002; 30: 91-6
7 Weitzman S, Egeler RM. Langerhans cell histiocytosis: Update for the pediatrician. Curr Opin Pediatr 2008; 20: 23-9
8 Chen HC, Shen WC, Chou DY, Chiang IP. Langerhans cell histiocytosis of the skull complicated with an epidural hematoma. AJNR Am J Neuroradiol 2002; 23: 493-5
9 Varsha D, Kaur M, Chaudhary N, Siraj F. Solitary Langerhans cell histiocytosis of the hard palate: A diagnostic pitfall. Ger Med Sci 2016; 14: Doc11
10 Vargas A, Ramírez H, Ramírez P, Foncea C, Venegas B, Astorga P. Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: A case report. Head Face Med 2016; 12: 21
11 Fiorini P, Gallesio C, Longoni V, Ramieri G. Eosinophilic granuloma of the mandible: Is a conservative treatment sufficient for local disease control?. J Craniofac Surg 2016; 27: e255-7
12 Xian D, Wang L, Chen J, Li J, Li J. Surgical excision of Langerhans cell histocytosis in condyloid process in adult. Zhonghua Kou Qiang Yi Xue Za Zhi 2015; 50: 126-7
13 Emmanouil D, Birpou E, Chatzidimitriou K, Matsioula C, Christopoulos P, Tosios K. et al. Hand-Schüler-Christian disease presenting with recurrent, bilateral, symmetrical mandibular lesions in an 8-year-old boy: Report of a case. Spec Care Dentist 2015; 35: 316-21
14 Vennamaneni NH, Majumdar S, Gautam NS, Uppala D. Langerhans cell histiocytosis (LCH) of the mandible in an adult: A rare case. BMJ Case Rep 2015;2015. pii: bcr2014207537.
15 Sherwani RK, Akhtar K, Qadri S, Ray PS. Eosinophilic granuloma of the mandible: A diagnostic dilemma. BMJ Case Rep 2014;2014. pii: bcr2013200274.
16 Liu J, Liu D, Zhou Y, Chen Q, Zeng X, Jin X. Langerhans cell histiocytosis with widespread ulcers and masses on the palate. Indian J Dermatol Venereol Leprol 2014; 80: 462-3
17 Zajko J. Mandibular Langerhans cell histiocytosis in an adult. Bratisl Lek Listy 2013; 114: 488-90
18 Felstead AM, Main BG, Thomas SJ, Hughes CW. Recurrent Langerhans cell histiocytosis of the mandible. Br J Oral Maxillofac Surg 2013; 51: 264-5
19 Alshadwi A, Nadershah M, AlBazie S. Langerhans cell histocytosis of the mandible in a pediatric patient. J Dent Child (Chic) 2013; 80: 145-9
20 Terada T. Recurrent multifocal Langerhans cell histiocytosis of the mandible and maxilla in a 46-year-old man: A pathologic case report. Int J Clin Exp Pathol 2013; 6: 939-42
21 Lee SH, Yoon HJ. Intralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: Report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 116: e255-60
22 Ge Y, Jing W, Liao X, Lin Y. Langerhans cell histiocytosis: A case report. Hua Xi Kou Qiang Yi Xue Za Zhi 2012; 30: 554-6
23 Yepes JF, Khalaf M, Cunningham L, Lindroth J. Chronic focal Langerhans cell histiocytosis of the left mandibular condyle presenting as limited jaw opening: A case report. Ear Nose Throat J 2012; 91: E26-30
24 Lajolo C, Campisi G, Deli G, Littarru C, Guiglia R, Giuliani M. et al. Langerhans’s cell histiocytosis in old subjects: Two rare case reports and review of the literature. Gerodontology 2012; 29: e1207-14
25 Shetty SK, Mamatha GS, Desai RS, Sable DM, Deshmukh VL, Ajwani HR. Bilateral gingival enlargement of the posterior mandible in an adolescent child. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114: 406-10
26 Aydin MA, Baykul T, Nasir S, Altuntaş SH, Türkaslan SS, Findik Y. et al. Misdiagnosed widespread eosinophilic granuloma of the mandible. J Craniofac Surg 2012; 23: e361-4
27 Anastasilakis AD, Kaltsas GA, Delimpasis G, Wilkens L, Kanakis G, Makras P. et al. Distinctive growth pattern in a patient with a delayed diagnosis of Langerhans’ cell histiocytosis. Pituitary 2012; 15 (01) S28-32
28 Martins MA, Gheno JL, Sant’Ana Filho M, Pinto Jr. DS, Tenis CA, Martins MD. et al. Rare case of unifocal Langerhans cell histiocytosis in four-month-old child. Int J Pediatr Otorhinolaryngol 2011; 75: 963-7
29 Murray M, Dean J, Slater L. Multifocal oral Langerhans cell histiocytosis. J Oral Maxillofac Surg 2011; 69: 2585-91
30 Baş B, Duran H, Şenyurt Ö, Günhan O. Eosinophilic granuloma: Resolution of lesion after biopsy. J Craniofac Surg 2011; 22: 2409-12
31 Dholam KP, Pusalkar HA, Kapadia KH. Implant retained prosthetic rehabilitation in the case of histiocytosis X of the mandible. Indian J Cancer 2011; 48: 262-4
32 Alloh Amichia YC, Le Bars P, Giumelli B, Soueidan A. Prosthetic rehabilitation after osteonecrosis of the jaws due to histiocytosis X and treatment with bisphosphonates apropos of a case. Odontostomatol Trop 2010; 33: 34-40
33 Muramatsu T, Hall GL, Hashimoto S, Miyauchi J, Shimono M. Clinico-pathologic conference: Case 4. Langerhans cell histiocytosis (LCH). Head Neck Pathol 2010; 4: 343-6
34 Park JW, Chung JW. Long-term treatment of Langerhans cell histiocytosis of the mandibular condyle with indomethacin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e13-21
35 Gaundong Mbéthé GL, Dejean C, Henriques de Figueiredo B, Sargos P, Italiano A, Kantor G. et al. Multifocal Langerhans cell histiocytosis of bone: Indications for radiotherapy. Cancer Radiother 2010; 14: 759-62
36 Altug HA, Alomeroglu M, Sahin S, Sencimen M, Dogan N, Krishnan DG. Incidental discovery of asymptomatic radiolucent lesion of the posterior mandible. J Oral Maxillofac Surg 2010; 68: 845-8
37 Esen A, Dolanmaz D, Kalayci A, Günhan O, Avunduk MC. Treatment of localized Langerhans’ cell histiocytosis of the mandible with intralesional steroid injection: Report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e53-8
38 Bouw FP, Nout E. A baby with a white lesion in the upper jaw. Ned Tijdschr Geneeskd 2009; 153: A231
39 Rees J, Paterson AW. Langerhans cell histiocytosis in an adult. Br J Oral Maxillofac Surg 2009; 47: 52-3
40 Helbling-Sieder C, Gebbers JO, Kuttenberger J. Eosinophilic granuloma of the mandible – A case report. Schweiz Monatsschr Zahnmed 2009; 119: 887-96
41 Guiglia R, Pizzo G, Aricò M, Maresi E, Compilato D, Campisi G. et al. Bifocal manifestation of eosinophilic granuloma in a pediatric patient. Med Sci Monit 2009; 15: CS95-9
42 Orzechowska-Wylegała B, Niedzielska I, Sobol G. Langerhans’ cell histiocytosis – Diagnostic and treatment difficulties. Pol Merkur Lekarski 2008; 24: 439-42
43 Ide F, Iwase T, Saito I, Umemura S, Nakajima T. Immunohistochemical and ultrastructural analysis of the proliferating cells in histiocytosis X. Cancer 1984; 53: 917-21
44 Shevale VV, Ekta K, Snehal T, Geetanjal M. A rare occurrence of Langerhans cell histiocytosis in an adult. J Oral Maxillofac Pathol 2014; 18: 415-9
45 Kannan K, Alwithanani N, Salama M, Kumar M, Uthappa R, Ahamed M. et al. Eosinophilic granuloma in jaw bone: A pare pediatric case report. Ethiop J Health Sci 2016; 26: 487-90
46 Favara BE, Jaffe R. The histopathology of Langerhans cell histiocytosis. Br J Cancer Suppl 1994; 23: S17-23
47 Mosnier I, Rondini-Gilli E, Crosara PT, Belmatoug N, Cyna-Gorse F, Cazals-Hatem D. et al. Langerhans’ cell histiocytosis of the labyrinth in adults. Otol Neurotol 2004; 25: 27-32
48 Loducca SV, Mantesso A, Araújo NS, Magalhães MH. Langerhans cell histiocytosis: Recurrent lesions affecting mandible in a 10-year-old patient. J Clin Pediatr Dent 2001; 25: 241-3