A Case Report and Review of B‑Lineage Acute Lymphoblastic Leukemias with Cannibalistic Lymphoblasts: A Unique Morphologic and Molecular Genetic Entity?

B K Bommannan; Man Updesh Singh Sachdeva; Shano Naseem; Alka Khadwal; Neelam Varma

doi:10.4103/ijmpo.ijmpo_280_20

Indian Journal of Medical and Paediatric Oncology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(06): 917-919
DOI: 10.4103/ijmpo.ijmpo_280_20

Case Report with Review of Literature

A Case Report and Review of B‑Lineage Acute Lymphoblastic Leukemias with Cannibalistic Lymphoblasts: A Unique Morphologic and Molecular Genetic Entity?

B K Bommannan

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

,

Man Updesh Singh Sachdeva

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

,

Shano Naseem

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

,

Alka Khadwal

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

,

Neelam Varma

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

› Institutsangaben

Abstract

Cannibalism is a type of “cell-in-cell” phenomenon commonly described in myeloid lineage malignancies. Although lymphocytes and their precursors are inherently non-phagocytic, there are sporadic case reports describing cannibalism by leukemic lymphoblasts. In the current manuscript, we report the case of a pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patient showing cannibalistic lymphoblasts and have reviewed the clinical and laboratory characteristics of similar cases documented in literature. Our manuscript highlights that all reported B-ALL patients showing cannibalistic lymphoblasts had intra-cytoplasmic vacuolations, and all such treatment-naïve pediatric patients were ETV6-RUNX1 fusion positive and had aberrant expression of myeloid lineage antigens.

Keywords

Cannibalism - ETV6-RUNX1 - pediatric - precursor B-lineage acute lymphoblastic leukemia

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