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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(01): 58-61
DOI: 10.4103/ijmpo.ijmpo_56_17
Original Article

Clinicopathological Profile and Treatment Outcomes of Bilateral Breast Cancer: A Study from Tertiary Cancer Center in South India

Linu Abraham Jacob
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Abhishek Anand
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Kuntegowdanahalli C. Lakshmaiah
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Govind K. Babu
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Dasappa Lokanatha
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
M.C. Suresh Suresh Babu
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Kadabur N. Lokesh
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Antapura Haleshappa Rudresha
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
L K. Rajeev
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Deepak Koppaka
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
› Institutsangaben Financial support and sponsorship Nil.
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Abstract

Background: Bilateral breast cancer (BBC) is a rare clinical entity with limited data regarding clinicopathological aspects and treatment guidelines. Materials and Methods: This was an observational study of patients diagnosed with BBC from August 2012 to July 2014. Synchronous breast cancers (SBCs) was defined as two tumors diagnosed within an interval of 6 months and metachronous breast cancer (MBC) as second cancer diagnosed after 6 months. Results: Out of 750 breast cancer patients seen during a 2-year period, 35 had BBC. Ten patients were diagnosed as SBC whereas 25 patients as MBC. Among patients with MBC, the average time for development of contralateral breast cancer was 5 years. In 8 patients, the contralateral breast cancer was detected mammography whereas rest 27 patients were detected by clinical breast examination. At a median follow-up of 24 months, 23 (66%) patients were disease free, 9 (26%) patients had disease relapse, and 3 (8%) patients succumbed to the progressive disease. Conclusions: Every patient with breast cancer should be regularly followed up with clinical breast examination at a more frequent interval. The role of frequent clinical breast examination appears more than mammography especially beyond 5 years for early detection of contralateral breast cancer.

Keywords

Bilateral breast cancer - metachronous breast cancer is - synchronous breast cancer


Publikationsverlauf

Artikel online veröffentlicht:
23. Juni 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Chaudary MA, Millis RR, Hoskins EO, Halder M, Bulbrook RD, Cuzick J. et al. Bilateral primary breast cancer: A prospective study of disease incidence. Br J Surg 1984; 71: 711-4
    CrossrefPubMedGoogle Scholar
  • 2 El HanchiZ, Berrada R, Fadli A, Ferhati D, Brahmi R, Baydada A. et al. Bilateral breast cancer. Incidence and risk factors. Gynecol Obstet Fertil 2004; 32: 128-34
    CrossrefPubMedGoogle Scholar
  • 3 Heron DE, Komarnicky LT, Hyslop T, Schwartz GF, Mansfield CM. Bilateral breast carcinoma: Risk factors and outcomes for patients with synchronous and metachronous disease. Cancer 2000; 88: 2739-50
    CrossrefPubMedGoogle Scholar
  • 4 Al-Jurf AS, Jochimsen PR, Urdaneta LF, Scott DH. Factors influencing survival in bilateral breast cancer. J Surg Oncol 1981; 16: 343-8
    CrossrefPubMedGoogle Scholar
  • 5 Cody 3rd HS. Routine contralateral breast biopsy: Helpful or irrelevant? Experience in 871 patients, 1979-1993. Ann Surg 1997; 225: 370-6
    CrossrefPubMedGoogle Scholar
  • 6 Gollamudi SV, Gelman RS, Peiro G, Schneider LJ, Schnitt SJ, Recht A. et al. Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. Cancer 1997; 79: 1362-9
    CrossrefPubMedGoogle Scholar
  • 7 Fritz A, Ries L, Sarin YK. SEER Extent of Disease-1998: Codes and Coding Instructions, Third Edition. Bethesda, Md: National Cancer Institute; January 1998.NIH Pub.No.98-2313
  • 8 Hartman M, Czene K, Reilly M, Adolfsson J, Bergh J, Adami HO. et al. Incidence and prognosis of synchronous and metachronous bilateral breast cancer. J Clin Oncol 2007; 25: 4210-6
    CrossrefPubMedGoogle Scholar
  • 9 Newman LA, Sahin AA, Cunningham JE, Bondy ML, Mirza NQ, Vlastos GS. et al. A case-control study of unilateral and bilateral breast carcinoma patients. Cancer 2001; 91: 1845-53
    CrossrefPubMedGoogle Scholar
  • 10 Vuoto HD, García AM, Candás GB, Zimmermann AG, Uriburu JL, Isetta JA. et al. Bilateral breast carcinoma: Clinical characteristics and its impact on survival. Breast J 2010; 16: 625-32
    CrossrefPubMedGoogle Scholar
  • 11 Chen Y, Thompson W, Semenciw R, Mao Y. Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev 1999; 8: 855-61
    PubMedGoogle Scholar
  • 12 Hislop TG, Elwood JM, Coldman AJ, Spinelli JJ, Worth AJ, Ellison LG. et al. Second primary cancers of the breast: Incidence and risk factors. Br J Cancer 1984; 49: 79-85
    CrossrefPubMedGoogle Scholar
  • 13 Takahashi H, Watanabe K, Takahashi M, Taguchi K, Sasaki F, Todo S. et al. The impact of bilateral breast cancer on the prognosis of breast cancer: A comparative study with unilateral breast cancer. Breast Cancer 2005; 12: 196-202
    CrossrefPubMedGoogle Scholar
  • 14 Levi F, Randimbison L, Te VC, La VecchiaC. Prognosis of bilateral synchronous breast cancer in Vaud, Switzerland. Breast 2003; 12: 89-91
    CrossrefPubMedGoogle Scholar
  • 15 Carmichael AR, Bendall S, Lockerbie L, Prescott R, Bates T. The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. Eur J Surg Oncol 2002; 28: 388-91
    CrossrefPubMedGoogle Scholar
  • 16 Kollias J, Ellis IO, Elston CW, Blamey RW. Prognostic significance of synchronous and metachronous bilateral breast cancer. World J Surg 2001; 25: 1117-24
    CrossrefPubMedGoogle Scholar
  • 17 Mose S, Adamietz IA, Thilmann C, Saran F, Bernhard M, Pahnke R. et al. Bilateral breast carcinoma versus unilateral disease. Review of 498 patients. Am J Clin Oncol 1997; 20: 541-5
    CrossrefPubMedGoogle Scholar
  • 18 Deo SV, Shridhar D, Purkayastha J, Bhutani M, Shukla NK, Raina V. et al. Therapeutic controversies in bilateral breast cancer. Clin Oncol (R Coll Radiol) 2003; 15: 297-8
    CrossrefPubMedGoogle Scholar
  • 19 Robinson E, Rennert G, Rennert HS, Neugut AI. Survival of first and second primary breast cancer. Cancer 1993; 71: 172-6
    CrossrefPubMedGoogle Scholar
  • 20 Hartmann LC, Schaid DJ, Woods JE, Crotty TP, Myers JL, Arnold PG. et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med 1999; 340: 77-84
    CrossrefPubMedGoogle Scholar
  • 21 Bernstein JL, Lapinski RH, Thakore SS, Doucette JT, Thompson WD. The descriptive epidemiology of second primary breast cancer. Epidemiology 2003; 14: 552-8
    CrossrefPubMedGoogle Scholar
  • 22 Li CI, Malone KE, Porter PL, Daling JR. Epidemiologic and molecular risk factors for contralateral breast cancer among young women. Br J Cancer 2003; 89: 513-8
    CrossrefPubMedGoogle Scholar
  • 23 Malone KE, Daling JR, Weiss NS, McKnight B, White E, Voigt LF. et al. Family history and survival of young women with invasive breast carcinoma. Cancer 1996; 78: 1417-25
    CrossrefPubMedGoogle Scholar
  • 24 Haagensen CD. Te natural history of breast cancer. In: Diseases of the Breast. Philadelphia: Saunders 1971; 2: S380-465
    Google Scholar
  • 25 Slack NH, Bross ID, Nemoto T, Fisher B. Experiences with bilateral primary carcinoma of the breast. Surg Gynecol Obstet 1973; 136: 433-40
    PubMedGoogle Scholar
  • 26 Hankey BF, Curtis RE, Boice JDJr, Flannery JT. A retrospective cohort analysis of second breast cancer risk for primary breast cancer patients with an assessment of the effect of radiation therapy. J Natl Cancer Inst 1983; 70: 797-804
    PubMedGoogle Scholar
  • 27 Storm HH, Jensen OM. Risk of contralateral breast cancer in Denmark 1943-80. Br J Cancer 1986; 54: 483-92
    CrossrefPubMedGoogle Scholar
  • 28 Robbins GF, Berg JW. Bilateral primary breast cancer; a prospective clinicopathological study. Cancer 1964; 17: 1501-27
    CrossrefPubMedGoogle Scholar
  • 29 Gong SJ, Rha SY, Jeung HC, Roh JK, Yang WI, Chung HC. et al. Bilateral breast cancer: Differential diagnosis using histological and biological parameters. Jpn J Clin Oncol 2007; 37: 487-92
    CrossrefPubMedGoogle Scholar
  • 30 Henderson IC, Patek AJ. The relationship between prognostic and predictive factors in the management of breast cancer. Breast Cancer Res Treat 1998; 52: 261-88
    CrossrefPubMedGoogle Scholar
  • 31 Mariani L, Coradini D, Biganzoli E, Boracchi P, Marubini E, Pilotti S. et al. Prognosic factors for metachronous contralateral breast cancer: A comparison of linear Cox regression model and its artifcial neural network expression. Breast Cancer Res Treat 1997; 44: 167-78
    CrossrefPubMedGoogle Scholar
  • 32 Saad RS, Denning KL, Finkelstein SD, Liu Y, Pereira TC, Lin X. et al. Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. Mod Pathol 2008; 21: 1200-7
    CrossrefPubMedGoogle Scholar
  • 33 Beckmann KR, Buckingham J, Craft P, Dahlstrom JE, Zhang Y, Roder D. et al. Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. Breast 2011; 20: 158-64
    CrossrefPubMedGoogle Scholar
  • 34 Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B. et al. Personalizing the treatment of women with early breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2013. Ann Oncol 2013; 24: 2206-23
    CrossrefPubMedGoogle Scholar
  • 35 Baker B, Morcos B, Daoud F, Sughayer M, Shabani H, Salameh H. et al. Histo-biological comparative analysis of bilateral breast cancer. Med Oncol 2013; 30: 711
    CrossrefPubMedGoogle Scholar
  • 36 Smith TJ. Breast cancer surveillance guidelines. J Oncol Pract 2013; 9: 65-7
    CrossrefPubMedGoogle Scholar
  • 37 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Breast Cancer Version 1. 2017-10 March, 2017
  • 38 Roder D, de SilvaP, Zorbas H, Kollias J, Malycha P, Pyke C. et al. Survival from synchronous bilateral breast cancer: The experience of surgeons participating in the breast audit of the society of breast surgeons of Australia and New Zealand. Asian Pac J Cancer Prev 2012; 13: 1413-8
    CrossrefPubMedGoogle Scholar
  • 39 Verkooijen HM, Chatelain V, Fioretta G, Vlastos G, Rapiti E, Sappino AP. et al. Survival after bilateral breast cancer: Results from a population-based study. Breast Cancer Res Treat 2007; 105: 347-57
    CrossrefPubMedGoogle Scholar