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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(04): 530-532
DOI: 10.4103/ijmpo.ijmpo_83_17
Case Report

Recurrent Metastatic High-Grade Osteosarcoma: Disease Stabilization and Successful Pregnancy Outcome following Aggressive Multimodality Treatment

Monica Khurana
Department of Hematology/Oncology, UCSF Benioff Children’s Hospital Oakland, Oakland, California 94609, USA
Department of Hematology/Oncology, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana 46202, USA
,
Barbara Gruner
Department of Pediatric Hematology/Oncology, University of Missouri School of Medicine, Columbia, Missouri 65201, USA
,
Bindu Kanathezhath Sathi
Department of Hematology/Oncology, UCSF Benioff Children’s Hospital Oakland, Oakland, California 94609, USA
Department of Pediatric Hematology/Oncology, University of Missouri School of Medicine, Columbia, Missouri 65201, USA
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Prognosis for refractory/recurrent metastatic osteosarcoma (OS) remains dismal with 3-year survival rates <20%. Achievement of more than 5 years of stable, refractory/recurrent metastatic OS disease in our patient is itself unique and attributable to multimodality therapy. Her high-dose chemotherapy regimen with alkylating agents did not lead to infertility, making her case even more unique. Successful disease stabilization and pregnancy outcome in our patient with metastatic multiple relapsed OS is one of the first cases published. We need further understanding and exploration of pathogenesis, chemoresistant mechanisms, and multimodality therapies including immunotherapy for OS.

Keywords

Cancer therapy - fertility - osteosarcoma


Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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