Indian Journal of Radiology and Imaging, Table of Contents CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2019; 29(01): 67-71DOI: 10.4103/ijri.IJRI_364_18 Case Report Upper limb peripheral neuropathy in sickle cell anemia: MR neurography appearances Feng Poh Radiologic Clinic, Medi-Rad Associates Ltd, Mt Elizabeth Hospital, Singapore 228510 Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 , Rocco Hlis Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 , Avneesh Chhabra Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX › Author Affiliations Subject Editor: Recommend Article Abstract Abstract Sickle cell anemia is an inherited disorder with many systemic complications. Peripheral neuropathy related to this disorder has been sparsely reported. We report an interesting case of upper limb peripheral neuropathy from sickle cell disease with emphasis on MR neurography appearances and electrophysiology correlation. Keywords KeywordsSickle cell anemia - peripheral neuropathy - MRI, MR neurography - MRN Full Text References References 1 Anemia, sickle cell. Introduction to Genes and Disease. Bethesda, Maryland: National Center for Biotechnology Information; 1998 2 Centers for Disease Control and Prevention. Sickle Cell Disease (SCD). 2016 3 Okuyucu EE, Turhanoglu A, Duman T, Kaya H, Melek IM, Yilmazer S. Peripheral nervous system involvement in patients with sickle cell disease. Eur J Neurol 2009; 16: 814-8 4 Kirson LE, Tomaro AJ. Mental nerve paresthesia secondary to sickle-cell crisis. Oral Surg Oral Med Oral Pathol 1979; 48: 509-12 5 Hamdoun E, Davis L, McCrary SJ, Eklund NP, Evans OB. Bilateral mental nerve neuropathy in an adolescent during sickle cell crises. J Child Neurol 2012; 27: 1038-41 6 Friedlander AH, Genser L, Swerdloff M. Mental nerve neuropathy: A complication of sickle-cell crisis. Oral Surg Oral Med Oral Pathol 1980; 49: 15-7 7 Gregory G, Olujohungbe A. Mandibular nerve neuropathy in sickle cell disease. Local factors. Oral Surg Oral Med Oral Pathol 1994; 77: 66-9 8 Asher SW. Multiple cranial neuropathies, trigeminal neuralgia, and vascular headaches in sickle cell disease, a possible common mechanism. Neurology 1980; 30: 210-1 9 Slavin ML, Barondes MJ. Ischemic optic neuropathy in sickle cell disease. Am J Ophthalmol 1988; 105: 212-3 10 Lana-Peixoto MA, Barbosa A. Anterior ischaemic optic neuropathy in a child with AS haemoglobinopathy and migraine. Br J Ophthalmol 1998; 82: 199-200 11 Shields Jr RW, Harris JW, Clark M. Mononeuropathy in sickle cell anemia: Anatomical and pathophysiological basis for its rarity. Muscle Nerve 1991; 14: 370-4 12 Roohi F, Gowda RM, Goel N, Kula RW. Mononeuropathy multiplex in sickle cell disease: A complication in need of recognition. J Clin Neuromuscul Dis 2001; 3: 63-9 13 Tsen LC, Cherayil G. Sickle cell-induced peripheral neuropathy following spinal anesthesia for cesarean delivery. Anesthesiology 2001; 95: 1298-9 14 Chang RW, Bell CL, Hallett M. Clinical characteristics and prognosis of vasculitic mononeuropathy multiplex. Arch Neurol 1984; 41: 618-21 15 Dyck PJ. Hypoxic neuropathy: Does hypoxia play a role in diabetic neuropathy? The 1988 Robert Wartenberg lecture. Neurology 1989; 39: 111-8 16 Nukada H, Dyck PJ. Microsphere embolization of nerve capillaries and fiber degeneration. Am J Pathol 1984; 115: 275-87 17 Carpenter EL, Bencardino J. Focus on advanced magnetic resonance techniques in clinical practice: Magnetic resonance neurography. Rad Clin N Am 2015; 53: 513-29 18 Bao H, Wang S, Wang G, Yang L, Hasan MU, Yao B. et al. Diffusion-weighted MR neurography of median and ulnar nerves in the wrist and palm. Eur Radiol 2017; 27: 2359-66 19 Takagi T, Nakamura M, Yamada M, Hikishima K, Momoshima S, Fujiyoshi K. et al. Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography. Neuroimage 2009; 44: 884-92