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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2017; 27(04): 447-456
DOI: 10.4103/ijri.IJRI_384_16
Neuro/Head & Neck

Comparison of fractional anisotropy and apparent diffusion coefficient among hypoxic ischemic encephalopathy stages 1, 2, and 3 and with nonasphyxiated newborns in 18 areas of brain

Authors

  • Supriya Kushwah

    Department of Paediatrics, Yenepoya Medical College, Mangalore, Karnataka, India

  • Ashok Kumar

    Department of Paediatrics, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India

  • Ashish Verma

    Department of Paediatrics, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India

  • Sriparna Basu

    Department of Paediatrics, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India

  • Ashutosh Kumar

    Department of Anaesthesia, KMC, Mangalore, Karnataka, India

Financial support and sponsorship Nil.
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Abstract

Purpose: To determine the area and extent of injury in hypoxic encephalopathy stages by diffusion tensor imaging (DTI) using parameters apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values and their comparison with controls without any evidence of asphyxia. To correlate the outcome of hypoxia severity clinically and significant changes on DTI parameter. Materials and Methods: DTI was done in 50 cases at median age of 12 and 20 controls at median age of 7 days. FA and apparent diffusion coefficient (ADC) were measured in several regions of interest (ROI). Continuous variables were analyzed using Student's t-test. Categorical variables were compared by Fisher's exact test. Comparison among multiple groups was done using analysis of variance (ANOVA) and post hoc Bonferroni test. Results: Abnormalities were more easily and accurately determined in ROI with the help of FA and ADC values. When compared with controls FA values were significantly decreased and ADC values were significantly increased in cases, in ROI including both right and left side of thalamus, basal ganglia, posterior limb of internal capsule, cerebral peduncle, corticospinal tracts, frontal, parietal, temporal, occipital with P value < 0.05. The extent of injury was maximum in stage-III. There was no significant difference among males and females. Conclusion: Compared to conventional magnetic resonance imaging (MRI), the evaluation of FA and ADC values using DTI can determine the extent and severity of injury in hypoxic encephalopathy. It can be used for early determination of brain injury in these patients.

Keywords

Apparent diffusion coefficient - diffusion tensor imaging - fractional anisotropy - hypoxic ischemic encephalopathy


Publication History

Article published online:
27 July 2021

© 2017. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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