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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2019; 29(04): 397-403
DOI: 10.4103/ijri.IJRI_385_19
Interventional Radiology

Stem cell therapy in critical limb ischemia: Current scenario and future trends

Arun Sharma
Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India
,
Mumun Sinha
Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India
,
Niraj Nirmal Pandey
Department of Radiodiagnosis, BRAIRCH, All India Institute of Medical Sciences, New Delhi, India
,
S H Chandrashekhara
Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India
› Institutsangaben Financial support and sponsorship Nil.
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Abstract

Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI.

Keywords

Critical limb ischemia - peripheral arterial disease - stem cell therapy


Publikationsverlauf

Eingereicht: 17. September 2019

Angenommen: 18. November 2019

Artikel online veröffentlicht:
21. Juli 2021

© 2019. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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