Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study

Ishan Kumar; Priyanka Aggarwal; Vineeta Gupta; Ashish Verma; Suwen Kumar; Ram C Shukla

doi:10.4103/ijri.IJRI_395_18

Indian Journal of Radiology and Imaging, Table of Contents

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2019; 29(01): 33-39
DOI: 10.4103/ijri.IJRI_395_18

Cardiac Radiology

Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study

Authors

Ishan Kumar

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Priyanka Aggarwal

Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Vineeta Gupta

Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Ashish Verma

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Suwen Kumar

Department of Cardiology, Queen’s Medical Center, Honolulu, Hawaii, USA
Ram C Shukla

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Subject Editor:

Abstract

Background: Cardiac iron deposition in transfusion-dependent thalassemia patients is patchy in distribution. Purpose: The purpose of this study is to assess the correlation between T2* matrices of membranous interventricular septum (MIVS) and T2* values of muscular interventricular septum (IVS) on magnetic resonance imaging (MRI) and to evaluate the relationship of myocardial T2* at these two locations with MRI-estimated liver iron concentrations (LIC) and electrocardiographic (ECG) parameters. Material and Methods: MRI of heart and liver was performed in 16 consecutive pediatric patients of transfusion-dependent thalassemia major to calculate liver iron concentration and T2* time of membranous and muscular IVS. ECG parameters of these patients were charted and correlated with MRI parameters. Results: No significant correlation between T2* values of muscular IVS and MIVS was observed. Mean T2* of MIVS (9.8 ms) was significantly lower than that of muscular IVS (26.9 ms). T2* of MIVS correlated strongly with LIC where as a weak correlation was observed between T2* of IVS and LIC. Significantly higher mean QTc (corrected QT interval) value (439.86 ms) was seen in patients with T2* IVS <20 ms. Conclusion: Addition of T2* analysis of MIVS to the existing MRI protocol, consisting of muscular IVS analysis, may offer a more sensitive estimation of cardiac iron overload.

Keywords

Cardiac - heart - magnetic resonance imaging - pediatrics - thalassemia

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References

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