Chronic myeloid leukemia with a rare fusion transcript, b2a3 (e13a3) BCR–ABL1: A report of four cases from India

Sudha Sazawal; Sunita Chhikara; Kanwaljeet Singh; Rekha Chaubey; Manoranjan Mahapatra; Tulika Seth; Renu Saxena

doi:10.4103/sajc.sajc_158_18

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(02): 107-123
DOI: 10.4103/sajc.sajc_158_18

Letter to Editor

Chronic myeloid leukemia with a rare fusion transcript, b2a3 (e13a3) BCR–ABL1: A report of four cases from India

Sudha Sazawal

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Sunita Chhikara

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Kanwaljeet Singh

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Rekha Chaubey

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Manoranjan Mahapatra

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Tulika Seth

Department of Hematology, All India Institute of Medical Sciences, New Delhi

,

Renu Saxena

Department of Hematology, All India Institute of Medical Sciences, New Delhi

› Author Affiliations

Abstract

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References

References
1 Verma D, Kantarjian HM, Jones D, Luthra R, Borthakur G, Verstovsek S, et al. Chronic myeloid leukemia (CML) with P190 BCR-ABL: Analysis of characteristics, outcomes, and prognostic significance. Blood 2009;114:2232-5.
2 Snyder DS, McMahon R, Cohen SR, Slovak ML. Chronic myeloid leukemia with an e13a3 BCR-ABL fusion: Benign course responsive to imatinib with an RT-PCR advisory. Am J Hematol 2004;75:92-5.
3 Liu B, Zhang W, Ma H. Complete cytogenetic response to nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. Mol Med Rep 2016;13:2635-8.
4 Liu LG, Tanaka H, Ito K, Kyo T, Ito T, Kimura A, et al. Chronic myelogenous leukemia with e13a3 (b2a3) type of BCR-ABL transcript having a DNA breakpoint between ABL exons a2 and a3. Am J Hematol 2003;74:268-72.
5 Moravcová J, Rulcová J, Polák J, Zemanová Z, Klamová H, Haskovec C, et al. CML patient with rare b 2 a 3 (e 13 a 3) variant of BCR-ABL transcript: Complete molecular response to imatinib. Leuk Res 2005;29:1365-6.
6 Pienkowska-Grela B, Woroniecka R, Solarska I, Kos K, Pastwińska A, Konopka L, et al. Complete cytogenetic and molecular response after imatinib treatment for chronic myeloid leukemia in a patient with atypical karyotype and BCR-ABL b2a3 transcript. Cancer Genet Cytogenet 2007;174:111-5.
7 Masuko M, Furukawa T, Abe T, Wada R, Maruyama S, Kitajima T, et al. A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement. Int J Hematol 2009;90:230-4.
8 Achkar WA, Wafa A, Ali BY, Manvelyan M, Liehr T. A rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-ABL e13a3 transcript and complex translocation involving four different chromosomes. Oncol Lett 2010;1:797-800.
9 McCarron SL, Langabeer SE, Bolger K, Haslam K, Crampe M, Kelly J, et al. Molecular response to imatinib in chronic myeloid leukaemia with a variant e13a3 BCR-ABL1 fusion. Med Oncol 2015;32:452.
10 Ha J, Cheong JW, Shin S, Lee ST, Choi JR. Chronic myeloid leukemia with rare variant b2a3 (e13a3) BCR-ABL1 fusion. Ann Lab Med 2016;36:287-9.
11 Melo JV. BCR-ABL gene variants. Baillieres Clin Haematol 1997;10:203-22.
12 Sazawal S, Chikkara S, Singh K, Chaubey R, Chandra D, Mishra P, et al. Chronic myeloid leukemia with a rare fusion transcript, e19a2 BCR-ABL1: A report of three cases from India. Ann Diagn Pathol 2017;27:24-7.
13 Nieborowska-Skorska M, Wasik MA, Slupianek A, Salomoni P, Kitamura T, Calabretta B, et al. Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL is dependent on intact Src homology (SH) 3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med 1999;189:1229-42.
14 Jinawath N, Norris-Kirby A, Smith BD, Gocke CD, Batista DA, Griffin CA, et al. A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia: Diagnostic challenges in clinical laboratory practice. J Mol Diagn 2009;11:359-63.