Multimodality treatment of head-and-neck soft-tissue sarcomas and short-term outcomes: Analysis from sarcoma medical oncology clinic

Ilavarasi Vanidassane; Aparna Sharma; Aditi Aggarwal; Sudhakar Gunasekar; Adarsh Barwad; Ekta Dhamija; Rambha Pandey; Suryanarayana Deo; Rakesh Garg; Sameer Rastogi

doi:10.4103/sajc.sajc_229_18

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(01): 69-71
DOI: 10.4103/sajc.sajc_229_18

ORIGINAL ARTICLE: Sarcomas

Multimodality treatment of head-and-neck soft-tissue sarcomas and short-term outcomes: Analysis from sarcoma medical oncology clinic

Ilavarasi Vanidassane

Department of Medical Oncology, IRCH, AIIMS, New Delhi

,

Aparna Sharma

Department of Medical Oncology, IRCH, AIIMS, New Delhi

,

Aditi Aggarwal

Department of Radiation Oncology, Lok Nayak Hospital, New Delhi

,

Sudhakar Gunasekar

Department of Surgical Oncology, IRCH, AIIMS, New Delhi

,

Adarsh Barwad

Department of Pathology, AIIMS, New Delhi

,

Ekta Dhamija

Department of Radiodiagnosis, IRCH, AIIMS, New Delhi

,

Rambha Pandey

Department of Radiation Oncology, IRCH, AIIMS, New Delhi

,

Suryanarayana Deo

Department of Surgical Oncology, IRCH, AIIMS, New Delhi

,

Rakesh Garg

Department of Oncoanaesthesia, IRCH, AIIMS, New Delhi

,

Sameer Rastogi

Department of Medical Oncology, IRCH, AIIMS, New Delhi

› Author Affiliations

Abstract

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Abstract

Background: Head-and-neck soft-tissue sarcomas (HNSTS) are extremely rare and lack definite guidelines. Methods: We retrospectively analyzed consecutive adult patients with HNSTS who presented to our sarcoma medical oncology clinic from January 2016 to October 2017. Results: There were a total of 30 patients. Unresectable localized disease was seen in 13 (43%) patients, metastatic disease 10 (34%) patients, while resectable disease in 7 (23%) patients only. Among unresectable localized disease, 3 (25%) patients could be converted to resectable disease after neoadjuvant therapy. Median follow period was 11 months. Progression-free survival was 19 months in patients with resectable disease and 6 months in patients with the unresectable/metastatic disease. Median OS was not reached. Conclusion: Unresectable HNSTS has a poor outcome. Neoadjuvant therapy can be tried in selected cases for achieving respectability or for vital organ preservation until robust data are available. A multidisciplinary approach for local control is crucial in managing unresectable HNSTS.

Key words

Head-and-neck sarcoma - multimodality treatment - neoadjuvant therapy - soft-tissue sarcoma - unresectable

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References

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