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CC BY-NC-ND 4.0 · South Asian J Cancer 2018; 07(04): 219-222
DOI: 10.4103/sajc.sajc_232_17
ORIGINAL ARTICLE: GI Cancers

Modified 5-fluorouracil/leucovorin/irinotecan as a feasible and efficacious second-line chemotherapeutic regimen in advanced gastric cancers

Autor*innen

  • Anant Ramaswamy

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Vikas Ostwal

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Kushal Gupta

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Vijai Simha

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Anup Toshniwal

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Nitin Shetty

    Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Chaitali Nashikkar

    Department of GIDMG, Tata Memorial Hospital, Mumbai, Maharashtrar

  • Sarika Mandavkar

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

  • Sudeep Gupta

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra

Financial support and sponsorship Nil.
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Abstract

Background: Modified 5-fluorouracil/leucovorin/irinotecan (mFOLFIRI) is a commonly used combination second-line chemotherapeutic regimen in advanced gastric cancer (AGC). Materials and Methods: Patients diagnosed with AGC, receiving biweekly mFOLFIRI between July 2013 and June 2016, as second-line chemotherapy were retrospectively analyzed for tolerance, prognostic factors, event-free survival (EFS), and overall survival (OS). Results: Overall, 91 patients were administered a median of 6 cycles of therapy. Response rate was 29.7% and clinical benefit rate was 57.2%. With a median follow-up of 11.5 months, median EFS was 3.98 months (95% confidence interval [CI]: 2.54–5.41) and median OS was 7.73 months (95% CI: 5.30–10.15). Common Grade 3 and Grade 4 adverse events were neutropenia (18.7%), febrile neutropenia (9.9%), thrombocytopenia (7.7%), and vomiting (4.4%). Nearly 33% of patients required dose modification during therapy. Conclusions: mFOLFIRI regimen as a second-line therapy in AGCs appears feasible and efficacious in clinical practice.

Key words

Advanced gastric cancers - modified 5-fluorouracil/leucovorin/irinotecan - second-line chemotherapy


Publikationsverlauf

Artikel online veröffentlicht:
21. Dezember 2020

© 2018. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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