Role of Cresp® in the management of chemotherapy-induced anemia in cancer patients: A real-world clinical practice audit

Ghanshyam Biswas; Avinash Pandey; Nikhil Ghadyalpatil; Nilesh Lokeshwar; Boben Thomas; Anita Ramesh; Yogesh Arora; Chandragouda Dodagoudar; Vibha Naik; Ashish Joshi; Indranil Ghosh; Rakesh Roy; Medhi Kunjahari; Tejinder Singh; Palanki Dattatreya Satya; Sachin Hingmire; Purvish M. Parikh

doi:10.4103/sajc.sajc_246_19

South Asian Journal of Cancer, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · South Asian J Cancer 2020; 09(01): 59-61
DOI: 10.4103/sajc.sajc_246_19

ORIGINAL ARTICLE: Supportive Care and Others

Role of Cresp® in the management of chemotherapy-induced anemia in cancer patients: A real-world clinical practice audit

Ghanshyam Biswas

Department of Medical Oncology, Sum Hospital, Bhubaneswar, Odisha

,

Avinash Pandey

Department of Medical Oncology, RCC, Patna, Bihar

,

Nikhil Ghadyalpatil

Department of Medical Oncology, Yashoda Hospital, Secunderabad, Telangana

,

Nilesh Lokeshwar

Department of Medical Oncology, Asian Cancer Institute, Mumbai, Maharashtra

,

Boben Thomas

Department of Medical Oncology, Kerala Institute of Medical Sciences, Trivandrum, Kerala

,

Anita Ramesh

Department of Medical Oncology, Apollo Specialty Hospital, Chennai, Tamil Nadu

,

Yogesh Arora

Department of Medical Oncology, Mohandai Oswal Hospital, Ludhiana, Punjab

,

Chandragouda Dodagoudar

Department of Medical Oncology, BLK Superspeciality Hospital, Delhi, NCR

,

Vibha Naik

Department of Medical Oncology, Naik Hospital, Baroda, Gujarat

,

Ashish Joshi

Department of Medical Oncology, Mumbai Oncocare Center, Mumbai, Maharashtra

,

Indranil Ghosh

Department of Medical Oncology, Apollo Hospital, Kolkata, West Bengal

,

Rakesh Roy

Department of Pain and Palliative Care, Saroj Gupta Cancer Hospital, Kolkata, West Bengal

,

Medhi Kunjahari

Department of Medical Oncology, Batra Cancer Center, Delhi, NCR

,

Tejinder Singh

Department of Medical Oncology, Fortis Hospital, Mumbai, Maharashtra

,

Palanki Dattatreya Satya

Department of Medical Oncology, Omega Hospital, Hyderabad, Telangana

,

Sachin Hingmire

Department of Medical Oncology, Deenanath Mangeshkar Hospital, Pune, Maharashtra

,

Purvish M. Parikh

Department of Medical Oncology, Shalby Cancer and Research Institute, Ahmedabad, Gujarat

› Institutsangaben

Abstract

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Abstract

Introduction: Anemia is a common, underestimated problem in cancer patients receiving myelosuppressive chemotherapy and has significant adverse effect on the quality of life and outcome. Darbepoetin has been shown to be effective in this setting, but controversy surrounds it actual use. Methods: We analyzed prospectively collected clinical practice data of patients receiving darbepoetin in a real-world setting for this retrospective audit. Patients with baseline hemoglobin (Hb) of <11 g/dl were included in this analysis. Their medical records were audited using a predetermined 35-point pro forma. Results: There were a total of 274 patients with advanced cancer receiving myelosuppressive chemotherapy who had baseline Hb <11 g/dl and who were given darbepoetin. Head-and-neck squamous cell carcinoma, lung cancer, and breast cancer were the most common cancers. Their median baseline Hb was 8.9 g/dl which rose to 11.2 g/dl at the end of commenced therapy, along with improved symptomatology. There were no new toxicities, and only two patients required discontinuation of darbepoetin due to toxicity. Conclusion: Darbepoetin is safe and effective in the prevention and management of anemia among patients receiving myelosuppressive chemotherapy.

Key words

Hemoglobin - India - prophylaxis - quality of life - quality of life

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Referenzen

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