Clinico-epidemiological features and response in childhood acute lymphoblastic leukemia at regional cancer center of Northeast India

Bhargab Jyoti Saikia; Partha Sarathi Roy; Gaurav Kumar; Rakesh Kumar Mishra; Anupam Sarma

doi:10.4103/sajc.sajc_249_19

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(04): 241-243
DOI: 10.4103/sajc.sajc_249_19

ORIGINAL ARTICLE: Hematolymphoid Malignancies

Clinico-epidemiological features and response in childhood acute lymphoblastic leukemia at regional cancer center of Northeast India

Authors

Bhargab Jyoti Saikia

Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam
Partha Sarathi Roy

Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam
Gaurav Kumar

Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam
Rakesh Kumar Mishra

Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam
Anupam Sarma

Department of Pathology, Dr. B Borooah Cancer Institute, Guwahati, Assam

Abstract

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Abstract

Introduction: Acute lymphoblastic leukemia (ALL) comprises 19.3% of all childhood cancers in Northeast India. Methods: We analyzed clinicoepidemiological features and early response to the treatment of all the cases of childhood ALL (age <15 years) diagnosed and treated at Dr. B Borooah Cancer Institute over 1 year. Results: Of 52 eligible cases, 69% were male (male:female ratio of 2.2:1) and the mean age was 7.1 years. Thirty-three children (63%) had baseline white blood cell count ≥20 × 109/L. Precursor B-cell was most the common subtype seen in 61% of children. Seven cases (14%) had high-risk (HR) cytogenetics, with t (9,22) being the most common one. Male sex and HR cytogenetics were significantly associated with poor early responses. Conclusion: ALL is a common childhood malignancy with high cure rates. However, poor socioeconomic status and the presence of higher proportions of disease-related factors lead to poor outcome in this part of the country.

Key words

Cytogenetics - early response - minimum residual disease - risk stratification

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References

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