A prospective randomized study comparing concurrent chemoradiation with weekly and 3 weekly cisplatin in locally advanced oropharyngeal carcinoma

R. Nanda; Aradhana Katke; N. Suneetha; B. Thejaswini; Tanvir Pasha; K. P. Jagannath; G. V. Giri; Govind K. Babu

doi:10.4103/sajc.sajc_270_18

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2019; 08(03): 178-182
DOI: 10.4103/sajc.sajc_270_18

ORIGINAL ARTICLE: Head and Neck Cancers

A prospective randomized study comparing concurrent chemoradiation with weekly and 3 weekly cisplatin in locally advanced oropharyngeal carcinoma

R. Nanda

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

Aradhana Katke

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

N. Suneetha

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

B. Thejaswini

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

Tanvir Pasha

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

K. P. Jagannath

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

G. V. Giri

Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

,

Govind K. Babu

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka

› Author Affiliations

Abstract

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Abstract

Introduction: The chemotherapy schedules with cytotoxic dose or weekly regimes are still challenging, weighing the benefits versus toxicities. This prospective randomized study is an attempt to assess the efficacy of two schedules of cisplatin in management of locally advanced HNSCC. Objectives: The objectives of this study was to evaluate tolerance, tumour response and toxicities of concurrent chemoradiation with cisplatin in weekly and three weekly regimes. Methods: Locally advanced oropharyngeal squamous cell carcinoma patients fit for concurrent chemoradiation with cisplatin 40 mg/m² (weekly) and 100 mg/m² (3 weekly) were randomized to Arm A and B concurrently with radiotherapy of 70Gy/35frs/7 weeks. Statistical Analysis: Chi-square/Fisher Exact test has been used to find the significance of study parameters on categorical scale between the groups. The statistical software SPSS 15.0 was used. Results: Between December 2010 and January 2013, 60 patients were enrolled. The median cycles of cisplatin in Arm-A was 5 and 2 in Arm-B. The complete response of 80.9% vs 75% and partial response of 14.3% vs 12.5% was observed in both arms respectively. There was no statistical difference in acute radiation and hematological toxicities between the two groups. With median follow up of 28 months, the 2 and 5 years overall survival was 55% and 58%; 41.6% and 32.3% in arms A and B respectively. Conclusion: In our study of locally advanced oropharyngeal carcinoma treated with radical radiotherapy comparing concurrent chemotherapy with cisplatin weekly vs 3 weekly had no significant difference in overall response, complete response and acute toxicities.

Key words

Advanced oropharyngeal carcinoma - concurrent chemoradiation - survival - 3 weekly and weekly cisplatin - toxicities

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References

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