Download PDF
CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(04): 366-372
DOI: 10.4103/wjnm.WJNM_115_18
Original Article

Software development for hepatopulmonary shunt estimation by gamma camera method in transarterial radioembolization

Ashish Jha Jha
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Sneha Mithun
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Ameya C. Puranik
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Nilendu Purandare
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Sneha Shah
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Archi Agrawal
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Suyash S. Kulkarni
1   Department of Raiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Nitin Shetty
1   Department of Raiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Venkatesh Rangarajan
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Trans-arterial radioembolization (TARE) is an established treatment for inoperable hepatocellular carcinoma and liver metastases from Carcinoma of gastrointestinal tract. Radiation-induced toxicity to the lung parenchyma is the dose-limiting factor in TARE. Pretreatment hepatopulmonary shunt (HPS) is estimated by gamma camera method by transarterial administration of 370MBq 99mTc macro aggregated albumin. We have developed HPS software on XELERIS-1.123 workstation, GE medical systems, Milwaukee, USA, for accurate calculation of HPS. This software has also been tested on a higher version of XELERIS workstation, and it has been found to work well in all versions.

Keywords

Hepatopulmonary shunt - transarterial radioembolization - Y-90 microspheres

Financial support and sponsorship

Nil.




Publication History

Received: 17 December 2018

Accepted: 18 May 2019

Article published online:
22 April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Owunwanne A, Patel M, Sadek S. Preparation, technetium-99m macroaggregated albumin. Handbook of Radiopharmaceuticals. Chapman and Hall; 1995. p. 67.
  • 2 Murthy R, Nunez R, Szklaruk J, Erwin W, Madoff DC, Gupta S, et al. Yttrium-90 microsphere therapy for hepatic malignancy: Devices, indications, technical considerations, and potential complications. Radiographics 2005;25 Suppl 1:S41-55.
  • 3 Salem R, Lewandowski RJ, Atassi B, Gordon SC, Gates VL, Barakat O, et al. Treatment of unresectable hepatocellular carcinoma with use of 90Y microspheres (TheraSphere): Safety, tumor response, and survival. J Vasc Interv Radiol 2005;16:1627-39.
  • 4 Salem R, Thurston KG. Radioembolization with yttrium-90 microspheres: A state-of-the-art brachytherapy treatment for primary and secondary liver malignancies: Part 3: Comprehensive literature review and future direction. J Vasc Interv Radiol 2006;17:1571-93.
  • 5 Kennedy A, Nag S, Salem R, Murthy R, McEwan AJ, Nutting C, et al. Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: A consensus panel report from the radioembolization brachytherapy oncology consortium. Int J Radiat Oncol Biol Phys 2007;68:13-23.
  • 6 TheraSphere™ yttrium-90 Glass Microspheres Instructions for use. Surrey, UK: Biocompatibles UK Ltd.; 2005. Available from: http://www.therasphere.com/physicians-packageinsert/TS_PackageInsert_USA_v12.pdf. [Last accessed on 2017 Jan 25].
  • 7 Sirtex Medical Limited. Sirtex Medical Training Manual, Training Program Physicians and Institutions. Australia: Sirtex Medical Limited; 2015. Available from: http://foxfireglobal.sirtex.com/sites/foxfireglobal.sirtex.com/files/user/trn-rw-04_for_eu_au_nz_and_asia.pdf. [Last accessed on 2017 Jan 25].
  • 8 Ziessman HA, Thrall JH, Yang PJ, Walker SC, Cozzi EA, Niederhuber JE, et al. Hepatic arterial perfusion scintigraphy with Tc-99m-MAA. Use of a totally implanted drug delivery system. Radiology 1984;152:167-72.
  • 9 Jha AK, Zade AA, Rangarajan V, Purandare N, Shah SA, Agrawal A, et al. Comparative analysis of hepatopulmonary shunt obtained from pretherapy 99mTc MAA scintigraphy and post-therapy 90Y bremsstrahlung imaging in 90Y microsphere therapy. Nucl Med Commun 2012;33:486-90.
  • 10 Jha AK, Purandare N, Shah SA, Agrawal A, Rangarajan V, Kulkarni SS. Is there a correlation between planar scintigraphy after 99mTc-MAA and 90Y administration? Nucl Med Commun 2016;37:107-9.
  • 11 Leung TW, Lau WY, Ho SK, Ward SC, Chow JH, Chan MS, et al. Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 1995;33:919-24.
  • 12 Yip D, Allen R, Ashton C, Jain S. Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol 2004;19:347-9.
  • 13 Goin JE, Salem R, Carr BI, Dancey JE, Soulen MC, Geschwind JF, et al. Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: Factors associated with liver toxicities. J Vasc Interv Radiol 2005;16:205-13.
  • 14 Szyszko T, Al-Nahhas A, Tait P, Rubello D, Canelo R, Habib N, et al. Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres. Nucl Med Commun 2007;28:21-4.
  • 15 Denecke T, Rühl R, Hildebrandt B, Stelter L, Grieser C, Stiepani H, et al. Planning transarterial radioembolization of colorectal liver metastases with yttrium 90 microspheres: Evaluation of a sequential diagnostic approach using radiologic and nuclear medicine imaging techniques. Eur Radiol 2008;18:892-902.