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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(03): 251-257
DOI: 10.4103/wjnm.WJNM_45_18
Original Article

Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga-gallgas in patients with chronic obstructive pulmonary disease: A pilot study

Enrique Gustavo Cuna
Physics Institute, Sciences Faculty, UDELAR, Montevideo, Uruguay
,
Juan Pablo Gambini
1   Center for Nuclear Medicine, Clinics Hospital, Medicine Faculty, UDELAR, Montevideo, Uruguay
,
Liliana Servente
2   Uruguayan Center for Molecular Imaging, CUDIM, Montevideo, Uruguay
,
Eduardo Savio
2   Uruguayan Center for Molecular Imaging, CUDIM, Montevideo, Uruguay
,
Henry William Engler
2   Uruguayan Center for Molecular Imaging, CUDIM, Montevideo, Uruguay
,
Gabriel Adrián González
Physics Institute, Sciences Faculty, UDELAR, Montevideo, Uruguay
,
Omar Alonso
1   Center for Nuclear Medicine, Clinics Hospital, Medicine Faculty, UDELAR, Montevideo, Uruguay
2   Uruguayan Center for Molecular Imaging, CUDIM, Montevideo, Uruguay
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Abstract

The aim of this study was quantitative comparison between 68Ga-Gallgas positron emission tomography (PET) and 99mTc-Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate-to-severe obstructive pulmonary disease and to identify image-derived texture features correlating to the physiologic parameters. Five patients with moderate-to-severe chronic obstructive pulmonary disease with PET and SPECT lung ventilation scans were selected for this study. Threshold-based segmentations were used to compare ventilated regions between both imaging techniques. Histograms of both scans were compared to reveal main differences in distributions of radiotracers. Volumes of segmentation as well as 50 textural features measured in the pulmonary region were correlated to the forced expiratory volume in 1 s (FEV1) as the relevant physiological variable. A better peripheral distribution of the radiotracer was observed in PET scans for three out of five patients. A segmentation threshold of 27% and 31% for normalized scans, for PET and SPECT respectively, was found optimal for volume correlation with FEV1. A high correlation (Pearson correlation coefficient >0.9) was found between 16 texture features measured from SPECT and 7 features measured from PET and FEV1. Quantitative measurements revealed different tracer distribution in both techniques. These results suggest that tracer distribution patterns may depend on the cause of the pulmonary obstruction. We found several texture features measured from SPECT to correlate to FEV1.

Keywords

Gallgas - quantification - technegas - texture features

Financial support and sponsorship

Funding from participating institutions.




Publikationsverlauf

Eingereicht: 02. Mai 2018

Angenommen: 13. Juli 2018

Artikel online veröffentlicht:
22. April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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