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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(03): 232-237
DOI: 10.4103/wjnm.WJNM_59_18
Original Article

Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography compared with diagnostic computed tomography in relapsed prostate cancer

Marcus Edward Asokendaran
1   Department of Nuclear Medicine, Fiona Stanley Hospital, Murdoch
,
Danielle P. Meyrick
2   Theranostics Australia, East Fremantle
,
Laura A. Skelly
3   TeleMed Health Services, Busselton, Bussell Highway, West Busselton
,
Nat P. Lenzo
1   Department of Nuclear Medicine, Fiona Stanley Hospital, Murdoch
2   Theranostics Australia, East Fremantle
4   Faculty of Health and Medical Sciences, UWA Medical School, Crawley, Australia
,
Andrew Henderson
5   Nuclear Medicine, Perth Radiological Clinic, Nedlands, Western Australia
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Abstract

The aim of this study was to evaluate if prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) has a higher detection rate compared to standard contrast CT imaging for patients with a rising prostate-specific antigen (PSA) following definitive treatment (i.e., curative radical prostatectomy, radiotherapy, and brachytherapy) for prostate cancer in a private hospital setting. A retrospective single-site clinical audit was conducted on 150 PSMA PET/CT scans done for patients with a rising PSA after definitive treatment for prostate cancer. All studies were performed using I and T Ga-68 PSMA produced on a Scintomics radiopharmaceutical unit (Munich). All scans were performed on a GE 710 PET/CT scanner. All studies were compared to standard CT and other imaging. Of the 150 patients who had a 68Gallium (Ga)-PSMA PET/CT for a rise in their PSA levels, 102/150 (68%) of patients had PSMA-avid scans compared to the conventional imaging group which had an overall detection rate of 42% (63/150). The rates of detection were 100%, 90%, 92%, 67%, and 25% at PSA levels of >10 μg/L, 5–10 μg/L, >1.5 μg/L, 0.5–1.5 μg/L, and <0.5 μg/L, respectively. PSMA PET/CT also solely picked up 39/102 (38%) of prostate cancer relapses compared to the conventional imaging group. In our study of 150 patients with biochemical recurrence of prostate cancer, 68Ga-PSMA PET/CT demonstrated a superior detection rate (P < 0.05) compared to conventional imaging, including patients with low PSA levels (<0.5 μg/L).

Keywords

68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography - biochemical relapse - prostate cancer

Financial support and sponsorship

Nil.




Publikationsverlauf

Eingereicht: 12. Juni 2018

Angenommen: 17. August 2018

Artikel online veröffentlicht:
22. April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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