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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(03): 258-265
DOI: 10.4103/wjnm.WJNM_66_18
Original Article

Efficacy and safety of 177Lutetium-prostate-specific membrane antigen therapy in metastatic castration-resistant prostate cancer patients: First experience in West Asia – A prospective study

Ramin Akbarian Aghdam
1   Cancer Research Center; Shahid Beheshti University of Medical Sciences, Tehran, Iran
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Mahasti Amoui
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Mohammadali Ghodsirad
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Sepide Khoshbakht
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Bahram Mofid
3   Department of Radiation Oncology, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Fateme Kaghazchi
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Mehrdad Tavakoli
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Elahe Pirayesh
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Hojjat Ahmadzadehfar
2   Department of Nuclear Medicine, Shohada′e Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4   Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
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Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed on the surface of prostate cancer (PC) cells, making it an excellent radiotracer for both therapeutic and diagnostic purposes. In this prospective study, we investigated the efficacy and toxicity of 177Lutetium (Lu)-PSMA in metastatic castration-resistant PC (mCRPC) patients for the establishment and approval of this therapy in Iran. Fourteen mCRPC patients (mean age 70.57 ± 7.3 years) were treated with a single dose of 177Lu-PSMA. Complete blood count, liver function tests (aspartate aminotransferase and alanine aminotransferase), alkaline phosphatase levels, renal function tests (urea and creatinine), and prostate-specific antigen (PSA) levels were obtained for the patients at baseline and every 2 weeks. A majority of the patients (11 patients, 64.2%) experienced a decline in their PSA levels; in 5 (45.4%) of these patients, the PSA levels declined > 50%.The severity of pain decreased in 8 (57.1%) patients, and performance status was improved in 5 (45.4%) patients. The treatment was well tolerated, and no severe hematological or nonhematological side effects were observed. Our findings show that 177Lu-PSMA had a high efficacy and a low toxicity in an Iranian population and is a promising treatment option for PC patients.

Keywords

177Lutetium - metastatic castration-resistant prostate cancer - prostate cancer - prostate-specific membrane antigen - radionuclide therapy - theranostic

Financial support and sponsorship

Financial support was obtained in the form of research grant from the Cancer Research Center, Shahid Beheshti University of Medical Sciences.




Publication History

Received: 08 July 2018

Accepted: 01 August 2018

Article published online:
22 April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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