An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay

Esmail Jafari; Hojjat Ahmadzadehfar; Habibollah Dadgar; Majid Assadi

doi:10.4103/wjnm.WJNM_78_19

World Journal of Nuclear Medicine, Table of Contents

CC BY-NC-ND 4.0 · World J Nucl Med 2020; 19(03): 260-265
DOI: 10.4103/wjnm.WJNM_78_19

Original Article

An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay

Esmail Jafari

⁰Department of Molecular Imaging and Radionuclide Therapy, The Persian Gulf Nuclear Medicine Research Center, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr

,

Hojjat Ahmadzadehfar

¹Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany

,

Habibollah Dadgar

²Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran

,

Majid Assadi

⁰Department of Molecular Imaging and Radionuclide Therapy, The Persian Gulf Nuclear Medicine Research Center, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr

› Author Affiliations

Abstract

Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with ⁶⁸Ga and ^99mTc allowed precise molecular imaging of prostate cancer and PSMA-targeted small molecule labeled with 177Lu leads to the development of radionuclide-targeted therapy of prostate cancer. Despite its name, it has been shown that PSMA has been expressed in several malignancies which can be due to significant neovascularization. Present pictorial assay reports the nonspecific tracer uptake in some malignancies during ⁶⁸Ga-PSMA positron-emission tomography/computed tomography imaging and ^99mTc-PSMA scintigraphy.

Keywords

68Ga-prostate-specific membrane antigen positron-emission tomography/computed tomography - ^99mTc-prostate-specific membrane antigen scintigraphy - prostate cancer - prostate-specific membrane antigen and nonspecific uptake

Full Text

References

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