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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(04): 437-439
DOI: 10.4103/wjnm.WJNM_84_18
Case Report

Infliximab-induced hot kidneys on bone scintigraphy

Derya Cayir
Department of Nuclear Medicine, University of Health Sciences, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
,
Mehmet Bozkurt
Department of Nuclear Medicine, University of Health Sciences, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
,
Mustafa Filik
1   Department of Nuclear Medicine, Ataturk University, Erzurum, Turkey
,
Salih Sinan Gultekin
Department of Nuclear Medicine, University of Health Sciences, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
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Abstract

99mTechnetium-methylene diphosphonate bone scintigraphy is widely used in various clinical settings to detect bone abnormalities. Many reasons may cause abnormal tracer uptake in soft tissues on bone scintigraphy. Here, we present a 70-year-old man diagnosed with rheumatoid arthritis receiving chimeric anti-tumor necrosis factor alpha (TNF-α) therapy (infliximab). In order to evaluate the bone involvement of rheumatic disease, the patient underwent a whole-body bone scan that revealed left side dominant diffuse uptake in both kidneys defined as the “hot kidneys.” Since the patient had no other identifiable reason, anti-TNF-α therapy might be responsible for the “hot kidneys” on bone scan. Thus, therapy regiment of the patient changed from the chimeric anti-TNF-α to a human monoclonal TNF inhibitor (golimumab). After 6 months of the change of the therapy, the bone scintigraphy was repeated and revealed that the previous “hot kidneys” finding had disappeared.

Keywords

99mTechnetium-methylene diphosphonate - anti-tumor necrosis factor alpha therapy - bone scintigraphy - hot kidneys

Financial support and sponsorship

Nil.




Publication History

Received: 28 September 2018

Accepted: 11 October 2018

Article published online:
22 April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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