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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(02): 137-142
DOI: 10.4103/wjnm.wjnm_36_18
Original Article

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Naima Al Bulushi
0   Department of Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat
,
Badriya Al Suqri
0   Department of Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat
,
Marwa Al Aamri
0   Department of Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat
,
Aymen Al Hadidi
1   Department of Radiology, Al Nahda Hospital, Muscat, Oman
,
Hafidh Al Jahdami
0   Department of Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat
,
Mohammed Al Zadjali
2   Department of Radiology, Royal hospital, Muscat, Oman
,
Mimouna Al Risi
2   Department of Radiology, Royal hospital, Muscat, Oman
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Abstract

The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15–75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation. Twenty-three patients had true positive Tc-99m-OCT scan. In addition to the primary tumors, the octreotide scan revealed metastasis in the lung, liver, and retroperitoneal lymph nodes. The smallest lesion detected on octreotide scan was a 4-mm pulmonary nodule that was missed on lung window CT scan. The Tc-99m-OCT had 17 true negative, one false negative, and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative, and one false positive. The overall sensitivity, specificity, accuracy, positive, and negative predictive values of Tc-99m-OCT scan were 96%, 100%, 97%, 100%, and 94%, respectively. Whereas those of CT and MRI were 78%, 94%, 85%, 94%, and 77%, respectively. Our diagnostic accuracy of Tc-99m-OCT is high. We recommend that, in addition to the conventional radiological investigations, Tc-99m-OCT scan, or other somatostatin receptor imaging (SSR) is a mandate for better and accurate staging of patients with NETs.

Keywords

Gallium-68 - indium-111 - neuroendocrine tumors - octreotide - somatostatin - technetium-99m

Financial support and sponsorship

Nil.




Publication History

Received: 00 00 2019

Accepted: 00 00 2019

Article published online:
22 April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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