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CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2016; 33(01): 032-036
DOI: 10.4322/jms.033101
Original Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Effects of aerobic exercise of different intensities in the liver of metabolic syndrome animals

L. A. C. Sousa
1   Laboratório de Estudos Morfoquantitativo e Imunohistoquímico - LEMI, Universidade São Judas Tadeu - USJT, Rua Taquari, 546, CEP 03166-000, São Paulo, SP, Brazil
,
S. C. M. Saucedo
1   Laboratório de Estudos Morfoquantitativo e Imunohistoquímico - LEMI, Universidade São Judas Tadeu - USJT, Rua Taquari, 546, CEP 03166-000, São Paulo, SP, Brazil
,
A. G. B. Veloso
1   Laboratório de Estudos Morfoquantitativo e Imunohistoquímico - LEMI, Universidade São Judas Tadeu - USJT, Rua Taquari, 546, CEP 03166-000, São Paulo, SP, Brazil
,
J. F. Machi
2   Unidade de Hipertensão, Instituto do Coração - InCor, Universidade de São Paulo - USP, Avenida Dr. Enéas de Carvalho Aguiar, 44, Pinheiros, CEP 05403-900, São Paulo, SP, Brazil
,
R. B. Wichi
3   Departamento de Educação Física, Faculdade Federal de Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, CEP 49060-108, Aracajú, SE, Brazil
,
E. M. Ornelas
1   Laboratório de Estudos Morfoquantitativo e Imunohistoquímico - LEMI, Universidade São Judas Tadeu - USJT, Rua Taquari, 546, CEP 03166-000, São Paulo, SP, Brazil
,
L. B. M. Maifrino
1   Laboratório de Estudos Morfoquantitativo e Imunohistoquímico - LEMI, Universidade São Judas Tadeu - USJT, Rua Taquari, 546, CEP 03166-000, São Paulo, SP, Brazil
4   Instituto de Cardiologia Dante Pazzaneze - IDPC, Avenida Dante Pazzanese, 500, CEP 04012-180, São Paulo, SP, Brazil
› Author Affiliations
Further Information

Publication History

12 December 2015

16 July 2016

Publication Date:
11 October 2018 (online)

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Abstract

Introduction: Metabolic syndrome (MS) corresponds to a sum of alteration in which, glucose intolerance is characterized as one of the most important. Among these are included: insulin resistance, type 2 diabetes mellitus, hypertension, obesity, dyslipidemia, endothelial dysfunction and others Nonalcoholic steatohepatitis (NASH) is also currently cited as a risk factor for MS Studies have demonstrated a strong correlation between physical inactivity and MS. The aim of this paper was to evaluate the effects of aerobic exercise training of different intensities on the liver of metabolic syndrome rats. Methods: 20 male Wistar rats were used and divided into four groups (n=5): control (C) sedentary MS (MS), walking MS (WMS) and running MS (RMS). Fructose-drinking rats received D-fructose (100 g/l). MS Training rats were assigned to a treadmill training protocol at low and moderate intensity during 1 h/day, 5 days/week for 8 weeks. At the end of the experiment, the livers were collected and submitted to a histological technique (HE). The images were captured and morphometric and stereological analysis of the hepatic tissue were performed. Results: It was verified that MS promoted a hypertrophy of the hepatocytes, a significant increase in the density volume of the hepatocytes, of the Kupffer cells, and hepatic sinusoids, and that, in both intensities (Running and Walking) the exercise training has mitigated the alterations. Conclusions: The data suggest, as nonpharmacological treatment, the walking (low intensity) is the most eficient, able to reverse the alterations caused by metabolic syndrome, the results being approximate to those of control group.

Keywords

liver - exercise - fructose - morphometry