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DOI: 10.4338/ACI-2015-09-RA-0125
Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure
Publication History
received:
02 October 2015
accepted:
07 February 2016
Publication Date:
16 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035026/201602/lookinside/thumbnails/10-4338-aci-2015-09-ra-0125-1.jpg)
Summary
Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART.
Citation: Rance B, Canuel V, Countouris H, Laurent-Puig P, Burgun A. Integrating heterogeneous biomedical data for cancer research: the CARPEM infrastructure.
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