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Hamostaseologie 2018; 38(02): 106-111
DOI: 10.5482/HAMO-16-12-0046
Case report
Schattauer GmbH Stuttgart

Acute Transmural Myocardial Infarction by Coronary Embolism in a Patient with JAK2 V617F-Positive Essential Thrombocythemia

Johannes Rotta detto Loria
1   Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Germany
,
Justyna Rawluk
2   Department of Hematology and Oncology, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
,
Tobias Krauss
3   Department of Radiology, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
,
Christoph Bode
1   Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Germany
,
Martin Moser
1   Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Germany
,
Thomas Helbing
1   Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Germany
› Author Affiliations
Further Information

Publication History

14 December 2016

10 July 2017

Publication Date:
29 May 2018 (online)

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Essential thrombocythemia (ET) is an acquired myeloproliferative disorder which results from malignant transformation of a multipotent hematopoietic progenitor cell. The disease is characterized by platelet count elevation (> 450 000 /µl) and augmented platelet reactivity causing thrombotic events and haemorrhages. The etiology of bleeding in ET is multifactorial and includes among others an acquired von Willebrand syndrome especially in the presence of extreme thrombocytosis (> 1 000 000 /µl). Thromboses can occur in arterial and venous vessels and are far more frequent than bleeding. Thrombotic complications are the major cause of morbidity and mortality in ET patients and do not correlate with platelet count.[1]

Herein, we report the case of a 53-year old man with low cardiovascular risk profile and untreated ET presenting with a transmural myocardial infarction (STEMI) in the territory of the left anterior descending and the right coronary artery most likely due to multiple coronary embolisation.