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DOI: 10.5935/1984-0063.20170018
Effect of a medicinal plant (Passiflora incarnata L) on sleep
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ABSTRACT
INTRODUCTION: Extracts of the plant Passiflora incarnata L. (Passifloraceae) were administered intraperitoneally in order to test its effects on sleep.
METHOD: Experiments were carried out on chronically implanted male adult wistar rats to obtain cerebral (EEG), ocular (EOG) and muscular (EMG) activities throughout their states of vigilance. Polygraphic recordings were taken during 9 continuous hours before and after the extract administration (500 mg/kg).
RESULTS: Passiflora incarnata induced a significant increment in the total sleep time (p<0.05). This increment was due to an increase in the time spent by animals in slow wave sleep (SWS). Concomitantly, a significant decrement in wakefulness (W) was observed (p<0.05). In contrast, time spent in rapid eye movement (REM) sleep showed a decreasing tendency, since both its frequency and mean duration were reduced.
CONCLUSIONS: The extracts obtained from Passiflora incarnata can be considered as appropriated sleep inducers.
Publication History
Received: 16 March 2017
Accepted: 25 July 2017
Article published online:
11 October 2023
© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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REFERENCES
- 1 Palaniappan K, Thenappan A. Physiological Basis of Alternative Therapies to Alleviate Sleep Disturbances. J Sleep Disord Ther. 2015;5:221. DOI: 10.4172/2167-0277.1000221
- 2 Johns MW. Sleep and hypnotic drugs. Drugs. 1975;9(6):448-78.
- 3 Hoffmann F. Benefits and risks of benzodiazepines and Z-drugs: comparison of perceptions of GPs and community pharmacists in Germany. Ger Med Sci. 2013;11:Doc10. DOI: 10.3205/000178
- 4 Costello RB, Lentino CV, Boyd CC, O'Connell ML, Crawford CC, Sprengel ML, et al. The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutr J. 2014;13:106. DOI: 10.1186/1475-2891-13-106.
- 5 Huang MP, Radadia K, Macone BW, Auerbach SH, Datta S. Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats. Behav Brain Res. 2010;210(1):54-66. DOI: 10.1016/j.bbr.2010.02.018
- 6 Vermeeren A. Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. 2004;18(5):297-328.
- 7 Ashton H. Guidelines for the rational use of benzodiazepines. When and what to use. Drugs. 1994;48(1):25-40.
- 8 Obach RS. Pharmacologically active drugs metabolites: impact on drug discovery and pharmacotherapy. Pharmacol Rev. 2013;65(2):578-640. DOI: 10.1124/pr.111.005439
- 9 Tortoriello J, Romero O. Plants used by Mexican traditional medicine with presumable sedative properties: an ethnobotanical approach. Arch Med Res. 1992;23(3):111-6. PMID: 1308799
- 10 Houghton PJ. The biological activity of Valerian and related plants. J Ethnopharmacol. 1988;22(2):121-42.
- 11 Tortoriello J, Ortega A. Sedative effect of Galphimine B, a Nor-seco-triterpenoid from Galphimia glauca. Planta Med. 1993;59(5):398-400.
- 12 Speroni E, Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54(6):488-91. DOI: 10.1055/s-2006-962525
- 13 Ngan A, Conduit R. A double-blind, placebo-controlled Investigation of the effects of Passiflora incarnate (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011;25(8):1153-9. DOI: 10.1002/ptr.3400
- 14 Leathwood PD, Chauffard F, Heck E, Muñoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav. 1982;17(1):65-71.
- 15 Gugliada R, Raggi A. Insomnia. Erboristeria Domani. 1991;10:46-54.
- 16 Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev. 2007;(1):CD004518.
- 17 Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, et al. Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biol Pharm Bull. 2005;28(5):808-10.
- 18 Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20.
- 19 Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss, G. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011;25(6):838-43. DOI: 10.1002/ptr.3352
- 20 Brown E, Hurd NS, McCall S, Ceremuga TE. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA J. 2007;75(5):333-7.