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CC BY-NC-ND 4.0 · Sleep Sci 2020; 13(02): 138-144
DOI: 10.5935/1984-0063.20190146
ORIGINAL ARTICLE

Effect of mild obstructive sleep apnea in mountaineers during the climb to Mount Aconcagua

Alvaro Emilio Ortiz-Naretto
1   Hospital Britanico de Buenos Aires, Medicine Respiratory Unit - Buenos Aires - CABA - Argentina.
2   Hospital Francisco Muñiz, Medicine Respiratory Unit - Buenos Aires - CABA - Argentina.
,
Miriam Patricia Pereiro
3   Hospital Materno Infantil R. Sardá, Laboratory - Buenos Aires - CABA - Argentina.
4   Hospital Pedro Fiorito, Laboratory - Avellaneda - Buenos Aires - Argentina
,
Glenda Ernst
1   Hospital Britanico de Buenos Aires, Medicine Respiratory Unit - Buenos Aires - CABA - Argentina.
,
Juan Manuel Aramburo
5   Laboratorio Dr. Aramburo, Laboratory - Mendoza - Argentina.
,
Ana María Tovo
3   Hospital Materno Infantil R. Sardá, Laboratory - Buenos Aires - CABA - Argentina.
,
Andres Vázquez-Fernández
6   Hospital Universitario Lucus Augusti, Clinical Medicine - Lugo - Spain.
,
Eduardo Borsini
1   Hospital Britanico de Buenos Aires, Medicine Respiratory Unit - Buenos Aires - CABA - Argentina.
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ABSTRACT

Objective: to compare mountaineers with and without asymptomatic sleep apnea (OSA) before the ascent and to study high altitude-related sleep disorders, its interaction with metabolic, neuroendocrine and immunological components.

Material and Methods: During an expedition to Mount Aconcagua, researchers assessed the respiratory polygraphy (RP), clinical condition and inflammatory parameters, and rhythm of cortisol secretion in mountaineers sleeping at different altitude camps.

Results: 8 athletes (4 women), 36 years old (25-51) participated. Baseline and final BMI were; 23.6 (20.9-28.7) and 22.77 (20.9-27.7), respectively: p<0.01. 40 valid RP recordings were analyzed. At 746 m.a.s.l. (baseline), only 2 mountaineers presented mild asymptomatic OSA. The OSA group presented baseline apnea-hypopnea index (AHI) values between 5-15 events per hour, which evidence a mild respiratory sleep disorder with AHI increased by altitude depending of central apneas and hypopneas (p<0.05) as high altitude periodic breathing pattern but no increase in obstructive apneas (p<0.01). The circadian rhythm of cortisol was maintained in all cases in which they had not received treatment with dexamethasone and their values increased with the altitude reached. Increased systolic blood pressure was observed in the OSA group.

Conclusion: In a context of hypobaric hypoxia, individuals with pre-existing asymptomatic OSA are prone to experiencing lower oxygen saturations and clinical deterioration.

Keywords:

Hypoxia - Altitude Sickness - Sleep Apnea Syndromes - Metabolic Syndrome


Publikationsverlauf

Eingereicht: 17. Februar 2019

Angenommen: 23. März 2020

Artikel online veröffentlicht:
09. November 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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