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CC BY-NC-ND 4.0 · Sleep Sci 2022; 15(03): 326-333
DOI: 10.5935/1984-0063.20220058
ORIGINAL ARTICLES

Effectiveness of a specific physical therapy program for Charcot-Marie-Tooth on sleep quality, pain perception, and nocturnal cramps: a pilot study

Cynthia Coelho Souza
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Julia Ribeiro da Silva Vallim
2   Universidade Federal de São Paulo, Departament of Psychobiology - São Paulo - São Paulo - Brazil
,
Eduardo Luis de Aquino Neves
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Paula Santos Nunes
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Iandra Maria Pinheiro de França Costa
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Lidiane Carine Lima Santos Barreto
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Catarina Andrade Garcez
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
,
Adriano Antunes de Souza Araujo
1   Universidade Federal de Sergipe, Departament of Pharmacy - Aracaju - Sergipe - Brazil
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Introduction Chronic pain, nocturnal cramps, and sleep alterations are prevalent symptoms and signals in Charcot-Marie-Tooth disease patients. Sleep and pain are bidirectionally related and physical therapy can improve the binomial sleep and pain/nocturnal cramps. Therefore, we hypothesized that the application of a specific physical therapy program for Charcot-Marie-Tooth disease would improve sleep quality, pain perception, and nocturnal cramps.

Material and Methods A non-randomized controlled study that included 9 Charcot-Marie-Tooth disease patients (intervention group - physical therapy program) and 8 controls (active control group - booklet on sleep hygiene). The intervention lasted 8 weeks, three sessions per week. The effects were evaluated ten days before (baseline) and ten days after the intervention (post). Our primary outcome was sleep quality (subjective and objective, assessed by Pittsburgh sleep quality index and actigraphy, respectively); and secondary outcomes were pain perception (brief pain inventory) and nocturnal cramps (self-report).

Results The program was able to improve the subjective sleep quality (p=0.005) and nocturnal cramps (p<0.001) but had no effect on actigraphy data (p>0.05) neither on pain perception (p>0.05).

Conclusion Our initial hypothesis was partially corroborated: the improvement in subjective quality of sleep and nocturnal cramps is already beneficial for the health promotion of the volunteers in this study affected by the disease. Our findings may serve as a basis for future research to develop a program focused on the treatment of analgesia, which can improve pain perception and alter the objective quality of sleep.

Musculoskeletal and Neural Physiological Phenomena - Actigraphy - Hereditary Sensory and Motor Neuropathy - Rehabilitation - Physical Therapy Modalities


Publication History

Received: 19 July 2021

Accepted: 17 January 2022

Article published online:
01 December 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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